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001386187 1001_ $$aMoss, Lenny.
001386187 24510 $$aWhat genes can't do /$$cLenny Moss.
001386187 260__ $$aCambridge, Mass. :$$bMIT Press,$$c©2003.
001386187 300__ $$a1 online resource (xx, 228 pages) :$$billustrations.
001386187 336__ $$atext$$btxt$$2rdacontent
001386187 337__ $$acomputer$$bc$$2rdamedia
001386187 338__ $$aonline resource$$bcr$$2rdacarrier
001386187 4901_ $$aBasic bioethics
001386187 506__ $$aAccess limited to authorized users.
001386187 5201_ $$a"The idea of the gene has been a central organizing theme in contemporary biology; and the Human Genome Project and biotechnological advances have put the gene in the media spotlight. In this book Lenny Moss reconstructs the history of the gene concept, placing it in the context of the perennial interplay between theories of preformationism and theories of epigenesis. He finds that there are not one, but two, fundamental - and fundamentally different - senses of "the gene" in scientific use: one the heir to preformationism and the other the heir to epigenesis. "Gene-P," the preformationist gene concept, serves as an instrumental predictor of phenotypic outcomes, whereas "Gene-D," the gene of epigenesis, is a developmental resource that specifies possible amino acid sequences for proteins. Moss argues that the popular idea that genes constitute blueprints for organisms is the result of an unwarranted conflation of these independently valid senses of the gene, and he analyzes the rhetorical basis of this conflation." "In the heart of the book, Moss uses the Gene-D/Gene-P distinction to examine the real basis of biological order and of the pathological loss of order in cancer. He provides a detailed analysis of the "order-from-order" role of cell membranes and compartmentalization and considers dynamic approaches to biological order such as that of Stuart Kauffman. He reviews the history of cancer research with an emphasis on the oncogene and tumor suppressor gene models and shows how these gene-centered strategies point back to the significance of higher level, multicellular organization fields in the onset and progression of cancer. Finally, Moss draws on the findings of the Human Genome Project, biological modularity, and the growing interest in resynthesizing theories of evolution and development to look beyond the "century of the gene" toward a rebirth of biological understanding."--Jacket.
001386187 588__ $$aOCLC-licensed vendor bibliographic record.
001386187 650_0 $$aGenetics$$xPhilosophy.
001386187 653__ $$aPHILOSOPHY/Ethics & Bioethics
001386187 653__ $$aBIOMEDICAL SCIENCES/General
001386187 655_0 $$aElectronic books
001386187 852__ $$bebk
001386187 85640 $$3MIT Press$$uhttps://univsouthin.idm.oclc.org/login?url=https://doi.org/10.7551/mitpress/7205.001.0001?locatt=mode:legacy$$zOnline Access through The MIT Press Direct
001386187 85642 $$3OCLC metadata license agreement$$uhttp://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf
001386187 909CO $$ooai:library.usi.edu:1386187$$pGLOBAL_SET
001386187 980__ $$aBIB
001386187 980__ $$aEBOOK
001386187 982__ $$aEbook
001386187 983__ $$aOnline