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Preface: Real World Evidence and Digital Innovation to Combat Noncommunicable DiseasesKelly H. Zou, Lobna A. Salem, Joseph P. Cook, Anurita Majumdar and Amrit Ray1. Real World Evidence Generation Joseph S. Imperato, Joseph P. Cook, Diana Morgenstern, Kim Gilchrist, Tarek A. Hassan, Jorge Saenz and Danute Ducinskiene2. Applications of RWE for Regulatory Uses Eleanor E. Panico, Corinne S. Pillai, Ewa Filipowska and Kelly H. Zou3. Patient Data Privacy, Protected Health Information and Ethics of Real-World EvidenceCorinne S. Pillai, Eleanor E. Panico, Kelly H. Zou and Ewa Filipowska4. Real-World Data, Big Data and Artificial Intelligence: Recent Development and Emerging Trends in the European Union Kelly H. Zou5. Patient Centricity and Precision Medicine Diana Morgenstern, Mina B. Riad, Claudia Zavala and Amrit Ray6. Health Information TechnologyJoseph P. Cook, Gabriel Jipa, Claudia Zavata and Lobna A. Salem7. Digital Health Technologies and Innovations Kelly H. Zou, Mina B. Riad, Shaantanu Donde, Joan van der Horn and Tarek A. Hassan8. Economic Analysis and Outcome Assessment Jean-Pascal Roussy and Kelly H. Zou9. Partnerships and Collaborations Salman Rizvi and Urooj A. Siddiqui10. Global Perspective: China Big Data Collaboration to Improve Patient Care Zhi Xia Xie, Jim Z. Li, Yvonne Huang, Olive Jin, Wei Yu and Kelly H. Zou11. The Future of Patient-Centric Data-Driven HealthcareKelly H. Zou, Lobna A. Salem and Amrit Ray