Problem A serious problem in the healthcare setting for patients who inject drugs (PWID) has been a lack of consistent screening for substance use, misuse of the vascular access device and the absence of an interprofessional communication plan designed to care for the patients primary presenting issue and the underlying addiction. Purpose The purpose of this capstone project was to develop an interprofessional communication model to facilitate improved care for the whole patient with a history of injectable drug use (IDU). Objective The objective of this project was to build and employ an interprofessional communication model to increase safety, decrease risks and improve outcomes for patients with a history of IDU requiring intravenous therapy. Plan The plan was to measure the interprofessional communication self-assessment, as it relates to serving PWID, prior to the implementation of a novel screening assessment tool and 90 days after initiation of the assessment to detect possible improvement in communication. Results Analyzing the results for all respondents pre- and post-intervention did not show significant change. Narrowing the analysis to RNs only for pre- and post-intervention in the interaction domain ρ = 0.023 shows a significant change in this domain. Focusing on the RNs only interaction domain the size of the effect was calculated using Eta Squared. The result for this group was η2 = 0.051 which is considered a small effect but close to a moderate effect. Calculating a Cohen’s d, the result was a moderate effect at Cohen’s d = 0.061. Recommendations An Interprofessional Communication Model is foundational to collaboration of care for PWID. Increasing safety, increasing successful completion of intravenous medication and decreasing cost begins with identification of the problem and communication to professionals involved in the care of the whole patient.