Title page
Copyright
Dedication
Contributors
Disclosures
Licensing Opportunities
Contents
Preface
1 Overview of Hematopoiesis and Immunology
Introduction
Hematopoiesis and Immunology
Across the Life Span
Hematopoietic Structure and Function
Immune Function: Cells and Responses
Organs of the Immune System
Summary
References
2 Basic Concepts of Transplantation
Introduction
Types of Hematopoietic
Stem Cell Transplants
Nonmyeloablative Hematopoietic Sources of Stem Cells Stem Cell Transplantation
Be The Match (National Marrow Donor Program)
Preparative Regimens
Clinical Evaluation
Patient and Family Education
Summary
References
3 Current Research
Introduction
Scientific Review Committee
Clinical Trials
Institutional Review Board
National Cancer Institute National
Clinical Trials Network
Resources for Clinical Investigation in
Blood and Marrow Transplantation
Nursing Research
Gene Therapy
Nonmalignant Diseases Treated With
Hematopoietic Stem Cell Transplantation
Summary
References
4 Considerations in Program Development and Sites of Care
Introduction
Initial Program Development
Care Continuum
Interprofessional Team
Nurse Leadership
Transplant Nurses and Professional
Development
Resource Utilization
Caregiver Support
Professional Transplant Community
Accreditation, Regulation, Quality Management and the Quality Plan
Summary Outcomes: Data, Reporting, and the Stem Cell Therapeutic Outcomes Database
References
5 Stem Cell Collection
Introduction
Bone Marrow Harvest
Evaluation of Autologous and
Allogeneic Donors for Collection
Peripheral Blood Stem Cell Collection
Mobilization of Stem Cells
Apheresis Issues
Allogeneic Blood Stem Cell Collection.

Mismatched and Haploidentical Donors
Unrelated Blood Stem Cell Collection
Pediatric Blood Stem Cell Collection
Psychological and Ethical Issues
Related to Stem Cell Donation
Cord Blood Stem Cell Transplantation
Stem Cell Processing
Future Directions
Stem Cell Manipulation
Summary
References
6 Transplant Treatment Course and Acute Complications
Introduction
Conditioning Regimens for Hematopoietic
Stem Cell Transplantation
Cellular Infusion of Hematopoietic
Stem Cells
After Stem Cell Infusion
Engraftment Phase
Summary
Patient and Caregiver Education
References
7 Acute and Chronic Graft-Versus-Host Disease
Introduction
Definitions
Acute Graft-Versus-Host Disease
Chronic Graft-Versus-Host Disease
Preventing and Treating Acute and
Chronic Graft-Versus-Host Disease
Strategies for Prophylaxis and Treatment
Components of Supportive Care
Preclinical and Developmental Strategies
for Prophylaxis, Treatment, and Control
Induction of Graft-Versus-Host Disease:
Preserving the Graft-Versus-Tumor Effect
Summary
References
8 Hematologic Effects
Introduction
Neutropenia
Thrombocytopenia
Anemia
Blood Product Transfusions
Delayed Engraftment
Late Post-Transplant Infections (More Than 100 Days)
Summary
References
9 Gastrointestinal Complications
Introduction
Mucositis
Salivary Gland Dysfunction
and Xerostomia
Nutrition
Taste Changes
Nausea and Vomiting
Diarrhea
Summary
References
10 Hepatorenal and Bladder Complications
Introduction
Hepatic Sinusoidal Obstruction Syndrome
Hepatitis
Kidney Injury
Transplant-Associated
Thrombotic Microangiopathy
Hemorrhagic Cystitis
Summary
References
11 Cardiopulmonary Complications
Introduction
Pulmonary Complications.

Nursing Care of Pulmonary Complications
Cardiac Complications
Nursing Care of Cardiac Complications
Summary
References
12 Neurologic Complications
Introduction
Neurotoxicities of Common Agents
Neurotoxicities of Infectious Diseases
Other Causes of Neurologic
Complications
Neurocognitive Dysfunction
Long-Term Neurotoxicities
Summary
References
13 Relapse and Subsequent Malignancies
Introduction
Relapse After Hematopoietic
Stem Cell Transplantation
High
Low
Subsequent Malignancies After
Hematopoietic Stem Cell Transplantation
Summary
References
14 Late Effects and Survivorship Care
Introduction
Survivorship Care
Late Infectious Complications
Vaccinations
Organ-Specific Toxicities
Relapse and Subsequent Malignancies
Health-Related Quality of Life
Caregivers
Summary
References
15 Ethical Considerations
Introduction
Transplantation as a Treatment Option:
Beneficence and Nonmaleficence
Informed Consent: Autonomous Decision
Patient Education: Preparing
for Treatment Outcomes
Donor Issues
Outcomes of Disease and Treatment:
Undesirable Consequences
Summary
References
16 Emerging Cellular Therapies: Chimeric Antigen Receptor T Cells
Introduction
Overview of the Immune System
and Immunotherapy
Building a Chimeric Antigen
Receptor T Cell
Mechanism of Action
Pivotal Trials
U.S. Food and Drug Administration
Approval
Five Steps to Chimeric Antigen
Receptor T-Cell Therapy
Toxicities and Side Effects of Chimeric
Antigen Receptor T-Cell Therapy
Building an Immunotherapy Program:
Teams and Infrastructure
Summary
References
17 Professional Practice
Introduction
Professional Regulation
Hematopoietic Stem Cell Transplantation
Nursing Specialty
Education.

Self-Care
Advocacy
Communication
Interprofessional Collaboration
Leadership
Professional Practice Evaluation
Evidence-Based Practice
Research
Summary
References
Index.