@article{1431626,
      recid = {1431626},
      author = {Belfo, João P. and Lemos, João M.},
      title = {Optimal impulsive control for cancer therapy/},
      pages = {1 online resource (ix, 102 pages)},
      abstract = {This Springer brief discusses the use of control  engineering methods to plan a cancer therapy which tends to  reduce tumour size in patients, striking a balance that  minimizes the toxic effects of the treatment. The authors  address the design and computation of impulsive control  therapies, a methodology previously underexplored in the  application of control methods to medical modelling. This  allows simulation of such discrete events as taking a pill  rather than relying on the supply of therapy being  continuous and steady. The book begins with an introduction  to the topic, before moving onto pharmacokinetic,  pharmacodynamical and tumour-growth models and explaining  how they describe the relationship between a certain  therapy plan and the evolution of cancer. This is placed  firmly in the context of work introducing impulsive  differential equations. The final chapter summarizes the  research presented and suggests future areas of research to  encourage readers in taking the subject forward.},
      url = {http://library.usi.edu/record/1431626},
}