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Table of Contents
Intro
Foreword
Preface
Contents
Part I: Basics
1: Animal Models for Brain Research
1.1 Introduction to Animal Modelling for Human Brain Disease
1.1.1 Relevance of Animal Models
1.1.2 Validity of Animal Models
1.1.2.1 Face Validity
1.1.2.2 Construct Validity
1.1.2.3 Aetiological Validity
1.1.2.4 Predictive Validity
1.1.3 Homology, Analogy and Isomorphism
1.1.4 Generalisation and Extrapolation
1.2 Animal Models of Psychiatric Disorders
1.2.1 The Endophenotype Concept in Psychiatry
1.2.2 Approaches to Modelling Psychiatric Disease
1.2.2.1 Behavioural Approach
1.2.2.2 Pharmacological Models
1.2.2.3 Genetic Models
1.2.3 Animal Models of Schizophrenia
1.2.3.1 Aetiology and Symptomatology of Schizophrenia
1.2.3.2 Validating Animal Models of Schizophrenia
Electrophysiological Endophenotypes
Cognitive Endophenotypes
Locomotor Activity
Sensory Discrimination
Negative Symptoms
1.2.3.3 Neurodevelopmental Schizophrenia Models
1.2.3.4 Drug-Induced Schizophrenia Models
Psychostimulant Models
Hallucinogen Models
1.2.3.5 Lesion-Induced Schizophrenia Models
1.2.3.6 Genetic Schizophrenia Models
Inbred and Selectively Bred Rodent Strains
Genetically Modified Models
1.3 Animal Models of Neurological Disorders
1.3.1 Approaches to Modelling Neurological Disorders
1.3.2 Animal Models of Alzheimer's Disease
1.3.2.1 Aetiology and Symptomatology of Alzheimer's Disease
1.3.2.2 Validating Animal Models of Alzheimer's Disease
Cognitive Symptoms
BPSD-Related Symptoms
Pathological Alterations
Neurochemical Alterations
1.3.2.3 Spontaneous and Selectively Bred Alzheimer's Disease Models
2.1.3.1 Volume of Distribution
2.1.3.2 Input Function
2.1.3.3 One-Tissue Compartment Model
2.1.3.4 Two-Tissue Compartment Model
2.1.3.5 Logan Plot
2.1.4 Reference Tissue Models
2.1.4.1 Binding Potential
2.1.4.2 Simplified Reference Tissue Model
2.1.5 Receptor Occupancy and Displacement
2.1.6 Semiquantitative Approach
2.1.7 Radioligands
2.2 PET Motion Correction: State of the Art
2.2.1 The Need for Awake PET: Anesthesia, Stress, and Its Impact on Small Animal PET
2.2.2 Motion Correction in PET Reconstruction
Foreword
Preface
Contents
Part I: Basics
1: Animal Models for Brain Research
1.1 Introduction to Animal Modelling for Human Brain Disease
1.1.1 Relevance of Animal Models
1.1.2 Validity of Animal Models
1.1.2.1 Face Validity
1.1.2.2 Construct Validity
1.1.2.3 Aetiological Validity
1.1.2.4 Predictive Validity
1.1.3 Homology, Analogy and Isomorphism
1.1.4 Generalisation and Extrapolation
1.2 Animal Models of Psychiatric Disorders
1.2.1 The Endophenotype Concept in Psychiatry
1.2.2 Approaches to Modelling Psychiatric Disease
1.2.2.1 Behavioural Approach
1.2.2.2 Pharmacological Models
1.2.2.3 Genetic Models
1.2.3 Animal Models of Schizophrenia
1.2.3.1 Aetiology and Symptomatology of Schizophrenia
1.2.3.2 Validating Animal Models of Schizophrenia
Electrophysiological Endophenotypes
Cognitive Endophenotypes
Locomotor Activity
Sensory Discrimination
Negative Symptoms
1.2.3.3 Neurodevelopmental Schizophrenia Models
1.2.3.4 Drug-Induced Schizophrenia Models
Psychostimulant Models
Hallucinogen Models
1.2.3.5 Lesion-Induced Schizophrenia Models
1.2.3.6 Genetic Schizophrenia Models
Inbred and Selectively Bred Rodent Strains
Genetically Modified Models
1.3 Animal Models of Neurological Disorders
1.3.1 Approaches to Modelling Neurological Disorders
1.3.2 Animal Models of Alzheimer's Disease
1.3.2.1 Aetiology and Symptomatology of Alzheimer's Disease
1.3.2.2 Validating Animal Models of Alzheimer's Disease
Cognitive Symptoms
BPSD-Related Symptoms
Pathological Alterations
Neurochemical Alterations
1.3.2.3 Spontaneous and Selectively Bred Alzheimer's Disease Models
2.1.3.1 Volume of Distribution
2.1.3.2 Input Function
2.1.3.3 One-Tissue Compartment Model
2.1.3.4 Two-Tissue Compartment Model
2.1.3.5 Logan Plot
2.1.4 Reference Tissue Models
2.1.4.1 Binding Potential
2.1.4.2 Simplified Reference Tissue Model
2.1.5 Receptor Occupancy and Displacement
2.1.6 Semiquantitative Approach
2.1.7 Radioligands
2.2 PET Motion Correction: State of the Art
2.2.1 The Need for Awake PET: Anesthesia, Stress, and Its Impact on Small Animal PET
2.2.2 Motion Correction in PET Reconstruction