001432153 000__ 04416cam\a2200601\i\4500 001432153 001__ 1432153 001432153 003__ OCoLC 001432153 005__ 20230309003426.0 001432153 006__ m\\\\\o\\d\\\\\\\\ 001432153 007__ cr\cn\nnnunnun 001432153 008__ 201031s2021\\\\sz\\\\\\o\\\\\000\0\eng\d 001432153 019__ $$a1198557437$$a1225367479$$a1237462650 001432153 020__ $$a9783030531768$$q(electronic bk.) 001432153 020__ $$a3030531767$$q(electronic bk.) 001432153 020__ $$z3030531759 001432153 020__ $$z9783030531751 001432153 0247_ $$a10.1007/978-3-030-53176-8$$2doi 001432153 035__ $$aSP(OCoLC)1202459056 001432153 040__ $$aEBLCP$$beng$$erda$$epn$$cEBLCP$$dEBLCP$$dYDXIT$$dYDX$$dUKAHL$$dOCLCF$$dOCLCO$$dGW5XE$$dOCLCO$$dOCL$$dSFB$$dDKU$$dOCLCO$$dOCLCQ$$dOCLCO$$dOCLCQ 001432153 049__ $$aISEA 001432153 050_4 $$aRC78.7.T62 001432153 050_4 $$aRC78.7.R4$$bD54 2020 001432153 08204 $$a616.07/575$$223 001432153 24500 $$aPET and SPECT of neurobiological systems /$$cRudi A.J.O. Dierckx, Andreas Otte, Erik F.J. de Vries, Aren van Waarde, editors ; Adriaan A. Lammertsma, guest editor. 001432153 250__ $$a2nd ed. 001432153 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2021] 001432153 300__ $$a1 online resource 001432153 336__ $$atext$$btxt$$2rdacontent 001432153 337__ $$acomputer$$bc$$2rdamedia 001432153 338__ $$aonline resource$$bcr$$2rdacarrier 001432153 500__ $$a2.2.3 Head Motion Tracking for Awake Small Animal PET. 001432153 5050_ $$aIntro -- Foreword -- Preface -- Contents -- Part I: Basics -- 1: Animal Models for Brain Research -- 1.1 Introduction to Animal Modelling for Human Brain Disease -- 1.1.1 Relevance of Animal Models -- 1.1.2 Validity of Animal Models -- 1.1.2.1 Face Validity -- 1.1.2.2 Construct Validity -- 1.1.2.3 Aetiological Validity -- 1.1.2.4 Predictive Validity -- 1.1.3 Homology, Analogy and Isomorphism -- 1.1.4 Generalisation and Extrapolation -- 1.2 Animal Models of Psychiatric Disorders -- 1.2.1 The Endophenotype Concept in Psychiatry -- 1.2.2 Approaches to Modelling Psychiatric Disease 001432153 5058_ $$a1.2.2.1 Behavioural Approach -- 1.2.2.2 Pharmacological Models -- 1.2.2.3 Genetic Models -- 1.2.3 Animal Models of Schizophrenia -- 1.2.3.1 Aetiology and Symptomatology of Schizophrenia -- 1.2.3.2 Validating Animal Models of Schizophrenia -- Electrophysiological Endophenotypes -- Cognitive Endophenotypes -- Locomotor Activity -- Sensory Discrimination -- Negative Symptoms -- 1.2.3.3 Neurodevelopmental Schizophrenia Models -- 1.2.3.4 Drug-Induced Schizophrenia Models -- Psychostimulant Models -- Hallucinogen Models -- 1.2.3.5 Lesion-Induced Schizophrenia Models 001432153 5058_ $$a1.2.3.6 Genetic Schizophrenia Models -- Inbred and Selectively Bred Rodent Strains -- Genetically Modified Models -- 1.3 Animal Models of Neurological Disorders -- 1.3.1 Approaches to Modelling Neurological Disorders -- 1.3.2 Animal Models of Alzheimer's Disease -- 1.3.2.1 Aetiology and Symptomatology of Alzheimer's Disease -- 1.3.2.2 Validating Animal Models of Alzheimer's Disease -- Cognitive Symptoms -- BPSD-Related Symptoms -- Pathological Alterations -- Neurochemical Alterations -- 1.3.2.3 Spontaneous and Selectively Bred Alzheimer's Disease Models 001432153 5058_ $$a2.1.3.1 Volume of Distribution -- 2.1.3.2 Input Function -- 2.1.3.3 One-Tissue Compartment Model -- 2.1.3.4 Two-Tissue Compartment Model -- 2.1.3.5 Logan Plot -- 2.1.4 Reference Tissue Models -- 2.1.4.1 Binding Potential -- 2.1.4.2 Simplified Reference Tissue Model -- 2.1.5 Receptor Occupancy and Displacement -- 2.1.6 Semiquantitative Approach -- 2.1.7 Radioligands -- 2.2 PET Motion Correction: State of the Art -- 2.2.1 The Need for Awake PET: Anesthesia, Stress, and Its Impact on Small Animal PET -- 2.2.2 Motion Correction in PET Reconstruction 001432153 506__ $$aAccess limited to authorized users. 001432153 650_0 $$aTomography, Emission. 001432153 650_0 $$aRadioisotope scanning. 001432153 650_6 $$aTomographie par émission. 001432153 650_6 $$aScintigraphie. 001432153 655_0 $$aElectronic books. 001432153 7001_ $$aDierckx, Rudi A. J. O. 001432153 7001_ $$aOtte, Andreas P.,$$d1967- 001432153 7001_ $$aVries, Erik F. J. de. 001432153 7001_ $$aWaarde, Aren van. 001432153 7001_ $$aLammertsma, Adriaan A. 001432153 77608 $$iPrint version:$$aDierckx, Rudi A.J.O.$$tPET and SPECT of Neurobiological Systems.$$dCham : Springer International Publishing AG, ©2020$$z9783030531751 001432153 852__ $$bebk 001432153 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-53176-8$$zOnline Access$$91397441.1 001432153 909CO $$ooai:library.usi.edu:1432153$$pGLOBAL_SET 001432153 980__ $$aBIB 001432153 980__ $$aEBOOK 001432153 982__ $$aEbook 001432153 983__ $$aOnline 001432153 994__ $$a92$$bISE