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001432251 020__ $$a9783030563196$$q(electronic bk.)
001432251 020__ $$a3030563197$$q(electronic bk.)
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001432251 0247_ $$a10.1007/978-3-030-56319-6$$2doi
001432251 035__ $$aSP(OCoLC)1202751599
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001432251 24504 $$aThe role of toll-like receptor 4 in infectious and non infectious inflammation /$$cCarlo Rossetti, Francesco Peri, editors.
001432251 260__ $$aCham :$$bSpringer,$$c2021.
001432251 300__ $$a1 online resource
001432251 336__ $$atext$$btxt$$2rdacontent
001432251 337__ $$acomputer$$bc$$2rdamedia
001432251 338__ $$aonline resource$$bcr$$2rdacarrier
001432251 4901_ $$aProgress in Inflammation Research ;$$vv. 87
001432251 5050_ $$aIntro -- Preface -- Contents -- About the Editors -- Chemically Synthesized TLR4 Ligands, Their Immunological Functions, and Potential as Vaccine Adjuvant -- 1 Introduction -- 2 Lipid A, a Stimulant of Innate Immunity -- 3 Vaccines Containing Natural LPS and Lipid A as Adjuvants -- 3.1 Cholera Vaccines -- 3.2 Salmonella Vaccines -- 3.3 Other Vaccines -- 4 LPS and Lipid A Derived from the Environment and from Fermented Foods as Adjuvant Candidates -- 5 Synthetic and Semi-synthetic Lipid As as Adjuvants -- 6 Developing Lipid A Adjuvant Candidates -- 7 Lipid A Based Self-adjuvant Vaccines
001432251 5058_ $$a8 Conclusions -- References -- Intracellular TLR4 Signaling -- 1 Introduction -- 2 TLR4/MyD88/NF-kB Pathway -- 3 TLR4/TRIF/IRF3 Branch -- 4 Regulation of the TLR4 Intracellular Signaling -- 5 Perspectives -- References -- TLR4 Ligands: Single Molecules and Aggregates -- 1 Basis of LPS Pathophysiology -- 2 Physico-Chemistry of the TLR4 Ligand LPS -- 3 Role of Aggregates in Biological Activity -- 4 From Aggregates to TLR4 Receptor Interaction -- 5 Non-LPS Ligands of TLR4: Aggregate States and Biological Activity -- 6 LPS Aggregates in the Activation of Non-TLR4 Receptors -- 7 Conclusions
001432251 5058_ $$a3.2.1 CD14 Controls Inflammatory Responses Against External Cues Other than LPS -- 3.2.2 CD14 Mediates the Responses to Endogenous Lipidic Stress Signals -- 3.2.3 CD14 Mediates the Responses to Endogenous Protein Stress Signals -- 4 Concluding Remarks -- References -- Toll-Like Receptor 4 Interactions with Neisseria -- 1 Introduction -- 2 Mechanism of TLR4 Interaction with Neisseria LOS -- 3 TLR4 in Neisseria meningitidis Infection -- 3.1 Influence of TLR4 Functional Polymorphisms on SMD -- 3.2 TLR4-LOS Inhibition Therapies -- 4 TLR4 in Neisseria gonorrhoeae Infection
001432251 5058_ $$a5 Exploiting TLR4 in Neisseria Vaccine-Induced Immune Responses -- 6 Conclusions -- References -- Toll-Like Receptor 4 Activation by Damage-Associated Molecular Patterns (DAMPs) -- 1 Introduction -- 2 Damage-Associated Molecular Patterns (DAMPs) -- 3 Heat Shock Proteins (HSPs) -- 4 Gp96 -- 5 HMGB1 -- 6 S100 Calcium Binding Proteins (Family of Calcium-Binding Cytosolic Proteins) -- 7 Hyaluronic Acid (HA) -- 8 Biglycans -- 9 Tenascin-C -- 10 Conclusion -- References -- TLR4 in Neurodegenerative Diseases: Alzheimer's and Parkinson's Diseases -- 1 Alzheimer's and Parkinson's Diseases -- 2 TLR4 in AD
001432251 506__ $$aAccess limited to authorized users.
001432251 520__ $$aTLR4 is one of the most important innate immunity receptors, its function mainly consisting in the activation of inflammatory pathways in response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs). This volume critically reviews the different types of TLR4 activators and inhibitors, discusses the role of molecular aggregates in agonism/antagonism as well as the pivotal role of the CD14 receptor in the modulation of TLR4 signal and the molecular details and actors of the intracellular cascade. The book presents the role of TLR4 in several pathologies, such as sepsis and septic shock caused by receptor activation by gram-negative bacterial lipopolysaccharide (LPS), in neurodegenerative and neurological diseases such as Parkinson and Alzheimer's diseases, and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of TLR4 in neural stem cell-mediated neurogenesis and neuroinflammation and in Human Induced Pluripotent Stem Cells and Cerebral Organoids and discusses the emerging role of micro-RNA (miRNA) regulation by TLR4.
001432251 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed January 21, 2021).
001432251 650_0 $$aInflammation$$xMediators.
001432251 650_0 $$aInflammation$$xImmunological aspects.
001432251 650_0 $$aCell receptors.
001432251 650_0 $$aProteins.
001432251 650_0 $$aImmunology.
001432251 650_0 $$aMedical microbiology.
001432251 650_0 $$aCommunicable diseases.
001432251 650_0 $$aCancer$$xResearch.
001432251 650_6 $$aInflammation (Pathologie)$$xMédiateurs.
001432251 650_6 $$aInflammation (Pathologie)$$xImmunologie.
001432251 650_6 $$aRécepteurs cellulaires.
001432251 650_6 $$aProtéines.
001432251 650_6 $$aImmunologie.
001432251 650_6 $$aMicrobiologie médicale.
001432251 650_6 $$aMaladies infectieuses.
001432251 650_6 $$aCancer$$xRecherche.
001432251 655_0 $$aElectronic books.
001432251 7001_ $$aRossetti, Carlo,$$eeditor.
001432251 7001_ $$aPeri, Francesco,$$eeditor.
001432251 77608 $$iPrint version:$$tRole of toll-like receptor 4 in infectious and non infectious inflammation.$$dCham : Springer, 2021$$z3030563189$$z9783030563189$$w(OCoLC)1176320959
001432251 830_0 $$aPIR (Series) ;$$vv. 87.
001432251 852__ $$bebk
001432251 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-56319-6$$zOnline Access$$91397441.1
001432251 909CO $$ooai:library.usi.edu:1432251$$pGLOBAL_SET
001432251 980__ $$aBIB
001432251 980__ $$aEBOOK
001432251 982__ $$aEbook
001432251 983__ $$aOnline
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