Intro
Preface to the Current Edition
Preface to the Fifth Edition
Contents
Contributors
1 Historical Aspects of Contact Dermatitis
1.1 Introduction
1.2 Historical Aspects of Patch Testing
1.2.1 The Pre-Jadassohn Period
1.2.2 Josef Jadassohn, the Father of Patch Testing in Dermatology
1.2.3 Jean-Henri Fabreś Experiments
1.2.4 A General Overview of Patch Testing During the Period 1895-1965
1.2.5 Bruno Blochś Pioneering Work in Basel and in Zurich
1.2.6 The Influence of Poul Bonnevie in Scandinavian Countries

1.2.7 Robert Prosser White, a Precursor in the Field of Occupational Dermatology
1.2.8 A Controversial Period: The Pros and Cons of a Baseline Series
1.2.9 Marion Sulzberger, the Initiator of Patch Testing in North America, and Alexander Fisher, a World Leader in the Field of ...
1.2.10 The Founding of Groups
1.2.11 The Founding of the European Environmental and Contact Dermatitis Research Group (EECDRG) and the European Society of C ...
1.2.12 Dermatochemistry and Contact Dermatitis
1.2.13 Recent Advances in the Management of Patch Testing

1.3 Historical Aspects of Prick Testing
References
Part I: Basic Features
2 Genetics and Individual Predispositions in Contact Dermatitis
2.1 General Introduction
2.2 Genetic Factors in Allergic Contact Dermatitis
2.2.1 Early Studies in the Genetics of Contact Allergy
2.2.1.1 Experimental Sensitization
2.2.1.2 Family Studies
2.2.1.3 Twin Studies
2.2.1.4 Studies of Immunogenetic Markers
2.2.2 In Search of the Phenotype of Contact Allergy: Polysensitization
2.2.3 Polymorphisms in Allergic Contact Dermatitis
2.2.3.1 Tumor Necrosis Factor (TNF)

Studies of TNF Polymorphisms in ACD (See Table 4)
2.2.3.2 Interleukin-16
Studies of IL-16 Polymorphisms in ACD
2.2.3.3 Chemokine CXCL-11
Studies of CXCL-11 Polymorphisms in ACD
2.2.3.4 Interleukin-10
Studies of IL-10 Polymorphisms in ACD
2.2.3.5 N-Acetyltransferase 1 and 2 (NAT1/NAT2)
Studies of NAT: Polymorphisms in ACD
2.2.3.6 Glutathione Transferases M1 and T1 (GSTM1 and GSTT1)
Studies of GSTM1 and GSTT1 Polymorphisms in ACD
2.2.3.7 Manganese Superoxide Dismutase
Studies of the MnSOD Polymorphisms in ACD
2.2.3.8 Angiotensin-Converting Enzyme

Studies of the ACE Polymorphisms in ACD
2.2.3.9 Filaggrin
Studies of FLG Mutations in ACD
2.2.3.10 Claudin-1
Studies of CLDN1 Mutations in ACD
2.2.3.11 General Remarks on the Study of ``Candidate Gene ́́Polymorphisms in ACD
2.2.4 Further Approaches
2.2.4.1 Allergen-Specific Susceptibility [193]
2.2.4.2 Genetic Controls Beyond DNA
2.2.4.3 Broadening the Focus on Pathology
2.3 Irritant Contact Dermatitis
2.3.1 Individual Variability in Irritant Responses in Healthy Individuals
2.3.2 Predisposition Related to Specific Phenotypes
2.3.2.1 Atopic Dermatitis