@article{1432779,
      recid = {1432779},
      author = {Fang, Dong and Han, Junhong},
      title = {Histone mutations and cancer /},
      pages = {1 online resource (vii, 96 pages) :},
      abstract = {"This book focuses on histone mutations, especially those  mutations closely related to cancer. Genetic mutations and  epigenetic alterations contribute to the development of a  variety of cancers: recent genetic studies have identified  e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG  cases, H3.3K36M mutation in more than 90% of  chondroblastoma cases, and H3G34W/L mutation in over 90% of  giant cell tumors of bone. Given the high incidence and  tumorigenesis effects of histone H3 mutations, they are  also referred to as oncohistones. This book highlights the  advances made in the area over the past 10 years, and  offers a state-of-the-art summary of epigenetic  alternation, gene expression, protein structure, drug  discovery, immunotherapy, and mouse modeling of histone H3  mutations in various tumors. Chiefly intended to provide  researchers and graduate students with an overall picture  of these mutations, it will also be of interest to  researchers in basic oncology, clinical oncology, and  epigenetics, as well as academics and clinical oncology  practitioners"--Publisher's description.},
      url = {http://library.usi.edu/record/1432779},
      doi = {https://doi.org/10.1007/978-981-15-8104-5},
}