001432779 000__ 03902cam\a2200661\i\4500
001432779 001__ 1432779
001432779 003__ OCoLC
001432779 005__ 20230309003532.0
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001432779 007__ cr\un\nnnunnun
001432779 008__ 201106t20212021si\a\\\\ob\\\\000\0\eng\d
001432779 019__ $$a1204176839$$a1206401993$$a1228844406$$a1232856355$$a1237412571$$a1246356869$$a1250096742
001432779 020__ $$a9789811581045$$qelectronic book
001432779 020__ $$a9811581045$$qelectronic book
001432779 020__ $$z9789811581038$$qhardcover
001432779 020__ $$z9811581037$$qhardcover
001432779 0247_ $$a10.1007/978-981-15-8104-5$$2doi
001432779 035__ $$aSP(OCoLC)1225558247
001432779 040__ $$aSFB$$beng$$erda$$cSFB$$dOCLCO$$dOCLCF$$dGW5XE$$dYDX$$dERF$$dUPM$$dEBLCP$$dOCLCO$$dMMU$$dOCLCO$$dOCL$$dOCLCO$$dOCLCQ$$dCASUM
001432779 049__ $$aISEA
001432779 050_4 $$aQP552.H5
001432779 08204 $$a572/.66$$223
001432779 24500 $$aHistone mutations and cancer /$$cDong Fang, Junhong Han, editors.
001432779 264_1 $$aSingapore :$$bSpringer,$$c[2021]
001432779 264_4 $$c©2021
001432779 300__ $$a1 online resource (vii, 96 pages) :$$billustrations (some color).
001432779 336__ $$atext$$btxt$$2rdacontent
001432779 337__ $$acomputer$$bc$$2rdamedia
001432779 338__ $$aonline resource$$bcr$$2rdacarrier
001432779 347__ $$atext file
001432779 347__ $$bPDF
001432779 4901_ $$aAdvances in experimental medicine and biology,$$x2214-8019 ;$$vvolume 1283
001432779 504__ $$aIncludes bibliographical references.
001432779 5050_ $$aOverview of histone modification -- The histone H3 family and its deposition pathways -- Histone H3K27M mutation in brain tumors -- Histone Mutations and Bone Cancers -- Histone H3G34 mutation in brain and bone tumors -- Epigenetic-targeted treatments for H3K27M-mutant midline gliomas -- Histone lysine to methionine mutation as anti-cancer drug target.
001432779 506__ $$aAccess limited to authorized users.
001432779 520__ $$a"This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners"--Publisher's description.
001432779 588__ $$aDescription based on online resource; title from electronic title page (ProQuest Ebook Central, viewed on June 17, 2021).
001432779 650_0 $$aHistones.
001432779 650_0 $$aMutation (Biology)
001432779 650_0 $$aCancer$$xResearch.
001432779 650_0 $$aGene expression.
001432779 650_0 $$aProteins.
001432779 650_6 $$aHistones.
001432779 650_6 $$aMutation (Biologie)
001432779 650_6 $$aCancer$$xRecherche.
001432779 650_6 $$aExpression génique.
001432779 650_6 $$aProtéines.
001432779 655_0 $$aElectronic books.
001432779 7001_ $$aFang, Dong$$c(Geneticist),$$eeditor.
001432779 7001_ $$aHan, Junhong$$c(Geneticist),$$eeditor.
001432779 77608 $$iPrint version:$$tHistone mutations and cancer.$$dSingapore : Springer, [2021]$$z9789811581038$$w(OCoLC)1180974841
001432779 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 1283.$$x0065-2598
001432779 852__ $$bebk
001432779 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-15-8104-5$$zOnline Access$$91397441.1
001432779 909CO $$ooai:library.usi.edu:1432779$$pGLOBAL_SET
001432779 980__ $$aBIB
001432779 980__ $$aEBOOK
001432779 982__ $$aEbook
001432779 983__ $$aOnline
001432779 994__ $$a92$$bISE