Concurrent users
Unlimited
Authorized users
Authorized users
Document Delivery Supplied
Can lend chapters, not whole ebooks
Title
Locoregional radionuclide cancer therapy : clinical and scientific aspects / Franklin C.L. Wong, editor.
ISBN
9783030562670 (electronic bk.)
3030562670 (electronic bk.)
9783030562663
3030562662
Published
Cham : Springer, [2021]
Language
English
Description
1 online resource (xii, 268 pages) : illustrations (some color)
Item Number
10.1007/978-3-030-56267-0 doi
Call Number
RC271.R3
Dewey Decimal Classification
616.99/40642
Summary
This book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach. Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed. This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.
Note
Includes index.
Access Note
Access limited to authorized users.
Digital File Characteristics
text file
PDF
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed February 25, 2021).
Available in Other Form
Print version: 3030562662
Human Cancer- Epidemiology, Hallmarks, and Defense Strategies
Cancer Treatment Modalities Systemic and Loco regional Approaches: Challenges and Opportunities of multidisciplinary approaches
Cancer Radiotherapy: General Considerations and Human Radiobiology
Radionuclide Cancer Therapy- Unsealed Alpha, Beta and Gamma Emitters
Locoregional Therapy
Cancer Interventions with and without Radionuclides
Radiation Dosimetry Considerations of Locoregional Radionuclide Cancer Therapy
Voxel-based Targeted Radionuclide Therapy Dosimetry
Locoregional Unsealed Radionuclide Cancer Therapy
Experimental Findings
Animal Cancer Therapy Models
Ready Translation to Humans
An Overview of Regulations of Radiopharmaceuticals
Locoregional Radionuclide Cancer Therapy (LRCT) Using Sealed & Unsealed Radionuclides.
