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Intro
Foreword
Preface
Contents
Contributors
Part I: Fundamentals and Systems
Chapter 1: Evidence on Mechanical Thrombectomy in Acute Ischemic Stroke
Goals of This Chapter
Landmark Papers
Langhorne P1, Williams BO, Gilchrist W, Howie K. Do Stroke Units Save Lives? Lancet. 1993 Aug 14
342(8868): 395-8
The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue Plasminogen Activator for Acute Ischemic Stroke. N Engl J Med 1995
333 (24): 1581-7
Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, et al.

ECASS Investigators. Thrombolysis with Alteplase 3 to 4.5 Hours After Acute Ischemic Stroke. N Engl J Med 2008
359 (13): 1317-29
Endovascular Treatment
Broderick JP, Palesch YY, Demchuk AM, Yeatts SD, Khatri P, Hill MD, et al. Endovascular Therapy After Intravenous t-PA versus t-PA Alone for Stroke. N Engl J Med. 2013
368:893-903 (IMS 3)
O. Bekhemer, F. Beumer, V. Berg, H Lingsma, Y. Schonewile, V. Nederkoom: The Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke (MR CLEAN). The New England Journal of Medicine, January 2015, vol 372

M. Goyal, A. Demchuk, B. Menon, M. Eesa, J. Rempel, J. Thornton, D. Roy: Randomized Assay of Rapid Endovascular Treatment of Ischemic Stroke (ESCAPE). The New England Journal of Medicine, February 2015
B. Campbell, P. Mitchell, T. Kleinig, H. Dewey, L. Churilov, N. Yassi: Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection (EXTEND -IA). The New England Journal of Medicine, February 2015

J. Saver, M. Mayank, A. Bonafe, M. Diener, P. Elad, I. Levy: Stent-Retriever Thrombectomy After Intravenous t-PA vs. t-PA Alone in Stroke (SWIFT PRIME). The New England Journal of Medicine, February 2015
Jovin, A. Chamorro, E. Cobo, M. Miquel, C. Molina, A. Rovira: Thrombectomy Within 8 Hours After Symptom Onset in Ischemic Stroke (REVASCAT). The New England Journal of Medicine, February 2015
Raul G. Nogueira, MD
Ashutosh P. Jadhav, MD, PhD
Diogo C. Haussen, MD
Alain Bonafe, MD
Ronald F. Budzik, MD
Parita Bhuva, MD

Et al. Thrombectomy 6 to 24 Hours After Stroke with a Mismatch Between Deficit and Infarct. N Engl J Med. January 4, 201
G.W. Albers, M.P. Marks, S. Kemp, S. Christensen, J.P. Tsai, S. Ortega-Gutierrez, et al. Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging. The New England Journal of Medicine, January 24, 2018
Recommendations and Level of Evidence
Time
RAPID Software to Select Patients for Late-Window Endovascular Therapy
Summary
Bibliography
Chapter 2: In Vitro Clot Modeling and Clinical Applications
Introduction
In Vitro Clot Modeling

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