Intro
Foreword
Foreword from ESSO
Foreword from the President of IHPBA
Foreword from the President of the AHPBA
Preface
Contents
Contributors
Part I: Pancreatic Cancer Disease Burden
Chapter 1: Risk Factors for Pancreatic Cancer
1.1 Introduction
1.2 Age, Gender and Race
1.3 Pancreatitis (Acute, Chronic and Hereditary)
1.3.1 Chronic Pancreatitis
1.3.2 Acute Pancreatitis
1.3.3 Hereditary Pancreatitis
1.4 Tobacco Smoking
1.5 Alcohol Consumption
1.6 Body Mass Index and Obesity
1.7 Diabetes Mellitus
1.8 Dietary Patterns

1.9 Poor Oral Hygiene
1.10 ABO Blood Group
1.11 Potential Risk Factors
1.12 Study Design and Ongoing Epidemiological Projects
1.13 Conclusions
References
Chapter 2: Epidemiology of Pancreatic Cancer
2.1 Introduction
2.2 Worldwide Incidence
2.3 Trends in Incidence
2.3.1 Data from The Netherlands
2.3.2 Data from Austria
2.3.3 Data from Canada
2.3.4 Data from Puerto Rico
2.3.5 Data from the USA
2.4 Worldwide Mortality
2.4.1 Data from The Netherlands
2.4.2 Data from Austria
2.4.3 Data from Canada
2.4.4 Data from Puerto Rico

2.4.5 Data from the USA
2.5 Conclusion
References
Chapter 3: Hereditary Syndromes and Pancreatic Cancer
3.1 Introduction
3.2 Hereditary Tumour Predisposition Syndromes
3.2.1 Peutz-Jeghers Syndrome
3.2.2 Familial Atypical Multiple Mole Melanoma and Pancreatic Cancer Syndrome (FAMMM)
3.2.3 Hereditary Breast and Ovarian Cancer Syndrome
3.2.4 PALB2 Gene Mutations
3.2.5 ATM Gene Mutations
3.2.6 Lynch Syndrome
3.3 Hereditary Pancreatitis
3.4 Other Tumour Predisposition Syndromes
3.4.1 Li Fraumeni Syndrome
3.4.2 Familial Adenomatous Polyposis

3.4.3 Germline Mutations in Other Cancer Genes
3.5 Testing and Tools
3.6 Surveillance/Screening Recommendations
3.7 Conclusion
References
Chapter 4: Familial Pancreatic Cancer
4.1 Introduction
4.2 Familial Pancreatic Cancer
4.3 Pancreatic Cancer Susceptibility Genes in Patients with Familial Pancreatic Cancer
4.3.1 ATM
4.3.2 BRCA1, BRCA2, PALB2
4.3.3 CDKN2A
4.3.4 Hereditary Pancreatitis Genes
4.3.5 Other Inherited Syndromes
4.4 Pancreatic Cancer Susceptibility Genes in Patients with Sporadic PDAC

4.5 Pancreatic Cancer Susceptibility Genes in Patients with Pancreatic Cancer Precursor Lesions
4.6 Screening for Patients with Pathogenic Germline Variants
4.7 Conclusion
References
Part II: Education, Training and Quality of Care
Chapter 5: Education and Training in Pancreatic Surgery
5.1 Structure of Training Pathways
5.1.1 North-American Training Programmes
5.1.2 European Training Programmes
5.1.3 Australasian Programmes
5.1.4 Effect of Training Programmes on Clinical Outcomes
5.1.5 Workforce Prediction
5.2 Standards of Training
5.2.1 Period of Training