Development of in-tether carbon chiral center-induced helical peptide : methodology and applications / Kuan Hu.
Hu, Kuan, author.
2021
QP552.P4
Available Online

Linked e-resources

Linked Resource Online Access
Concurrent users Unlimited
Authorized users Authorized users
Document Delivery Supplied Can lend chapters, not whole ebooks

Details

Title Development of in-tether carbon chiral center-induced helical peptide : methodology and applications / Kuan Hu.
Author Hu, Kuan, author.
ISBN 9789813366138 (electronic book)
9813366133 (electronic book)
9813366125
9789813366121
DOI https://doi.org/10.1007/978-981-33-6613-8
Published Singapore : Springer, [2021]
Language English
Description 1 online resource (xv, 102 pages) : illustrations (some color)
Item Number 10.1007/978-981-33-6613-8 doi
Call Number QP552.P4
Dewey Decimal Classification 572/.65
612/.015756
Summary This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein-protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely "chiral center induced peptide helicity (CIH)". The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers' understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs
Note "Doctoral thesis accepted by Peking University, Beijing, China."
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed March 9, 2021).
Series Springer theses, 2190-5053
Available in Other Form Print version: 9789813366121
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
All Resources
Introduction
Synthesis of in-tether chiral center peptides and their biophysical properties study
In-tether chiral center induced helical peptide modulators target p53-MDM2/MDMX and inhibit tumor growth in cancer stem cell
Summary and conclusion.

Browse Subjects

Show more subjects...

Statistics

from
to
Export