Intro
Preface
Contents
Chapter 1: Gene Structure, Expression, and 5-HT2B Receptor Signaling
1 5-HT2B Receptor Gene Expression and Regulation
1.1 5-HT2B Receptor Expression
1.2 Genomic Organization and Control of the 5-HT2B Receptor Gene HTR2B
2 Structure and Pharmacological Impact
2.1 5-HT2B Receptor Structure
2.2 Selective Agonists
2.3 Selective Antagonists
2.4 Allosteric Modulators
2.5 Biased Agonists
3 5-HT2B Receptor Heteromeric Receptor Associations
3.1 Heterodimers of Gq-Coupled Protomers: 5-HT2A, 5-HT2B, and 5-HT2C Receptors

3.2 Heterodimers Among Gq-Activating Protomers: AT1-5-HT2B Heterodimers
4 5-HT2B Receptor Internalization
5 5-HT2B Receptor Interacting Proteins
6 5-HT2B Receptor Transduction System(s)
6.1 In Transfected Cells
6.2 Heart
6.3 Liver
6.4 Lung
6.5 Skin
6.6 Bones
7 5-HT2B Receptor in Cancer Cells
7.1 Carcinoid Tumors
7.2 Melanoma
7.3 Adrenocortical Carcinoma
7.4 Hepatocellular Carcinoma
7.5 Pancreatic Ductal Adenocarcinomas
7.6 T-cell Leukemia
7.7 Tumor Angiogenesis
8 Outlook and Prospects
References
Part I: Development and Growth

Chapter 2: Serotonin Function During Embryonic Development: The 5-HT2B Receptor Contribution
1 Introduction
2 A Main Mediator of Serotonergic Signaling During Embryogenesis: The 5-HT2B Receptor
3 Role of 5-HT2B Receptor in Cardio Vascular Development
4 Role of 5-HT2B Receptor in Hematopoietic Lineage
5 Role of 5-HT2B Receptor in Osteogenesis
6 Role of 5-HT2B Receptor in Neural Crest Cells (NCC)
6.1 5-HT2B Receptor in Craniofacial Development
6.2 5-HT2B Receptor in Ocular Development
6.3 5-HT2B Receptor in NCC Derivatives of the Gut

6.4 5-HT2B Receptor in NCC Derivatives of the Skin
References
Chapter 3: Stem Cells to Decipher the Physiological Roles of 5-HT2B Receptor Signaling
1 Introduction
2 The 1C11 Neuronal Stem Cell Line to Dissect the Role of 5-HT2BRs in Bioaminergic Neurons
2.1 5-HT2BRs are Involved in the Neuronal Differentiation Program of 1C11 Stem Cells
2.2 The Onset of Serotonergic Functions Mainly Depends on Post-Transcriptional Controls
2.3 Identification of 5-HT2BR Couplings Along the 1C11 Serotonergic Differentiation

2.4 The 5-HT2BR Acts as a 5-HT Biosensor that Adjusts 5-HT Levels by Controlling SERT Functionality
2.5 5-HT2BR Signaling is Modulated by the Cellular Prion Protein in Serotonergic 1C11 Cells
3 Role of the 5-HT2B Receptor in Mineralized Tissues
3.1 The 5-HT2BR Controls TNAP Activity During Osteogenic Differentiation of the C1 Mesodermic Stem Cells
3.2 Pulpal Stem Cell Lines to Reveal the Critical Role of Serotonergic (5-HT2B,7R) and Dopaminergic (D1,3R) Autoreceptors in Platelet-Mediated Tooth Repair
4 Conclusion
References