Essentials of blood product management in anesthesia practice / Corey S. Scher, Alan David Kaye, Henry Liu, Seth Perelman, Sarah Leavitt, editors.
Scher, Corey S., editor.; Kaye, Alan David, editor.; Liu, Henry, editor.; Perelman, Seth, editor.; Leavitt, Sarah, editor.
2021
RD82
Available Online

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Title Essentials of blood product management in anesthesia practice / Corey S. Scher, Alan David Kaye, Henry Liu, Seth Perelman, Sarah Leavitt, editors.
ISBN 9783030592950 (electronic bk.)
3030592952 (electronic bk.)
9783030592967 (print)
3030592960
9783030592974 (print)
3030592979
9783030592943
3030592944
DOI https://doi.org/10.1007/978-3-030-59295-0
Published Cham : Springer, [2021]
Language English
Description 1 online resource
Other Standard Identifiers 10.1007/978-3-030-59295-0 doi
Call Number RD82
Dewey Decimal Classification 617.9/6
Summary This comprehensive book is written to inform and improve outcomes of patients in need of blood management during surgical procedures. Information is presented in an accessible format, allowing for immediate use in clinical practice. Beginning with an overview of the history of blood transfusions, early chapters present the foundational information needed to comprehend information in later chapters. Nuanced procedures, drugs, and techniques are covered, including new biologicals to assist clotting and blood substitutes. Further discussions focus on potential complications seen in blood transfusions, such as diseases of the coagulation system, pathogen transmissions, and acute lung injuries. Chapters also examine the complexities of treating specific demographics, of which include the geriatric patient and patients suffering from substance abuse. Essentials of Blood Product Management in Anesthesia Practice is an invaluable guide for anesthesiologists, surgeons, trauma physicians, and solid organ transplant providers.
Note Includes index.
Access Note Access limited to authorized users.
Digital File Characteristics text file
PDF
Source of Description Online resource; title from PDF title page (SpringerLink, viewed April 12, 2021).
Added Author Scher, Corey S., editor.
Kaye, Alan David, editor.
Liu, Henry, editor.
Perelman, Seth, editor.
Leavitt, Sarah, editor.
Available in Other Form Print version: 9783030592943
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
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Intro
Foreword
Contents
Contributors
1: The History of Blood Transfusion and Blood Management
Introduction
The Legacy of Hippocrates
Antiquity and the Concept of Transfusion
The Discovery of the Circulation
The Cellular Elements of Blood
The Royal Society Transfusion Experiments
James Blundell and Obstetricians Revive Transfusion Medicine
The Legacy of Karl Landsteiner
The Search for an Anticoagulant
Fractionated Blood Products
Blood Management in the Modern Era
The Future of Blood Management
References
2: Modern Blood Banking

The ABO and Rh Blood System
Other Blood Antigen Systems
The Human Leukocyte Antigen System
Alloimmunization
Inventory Management
RBC Considerations
Platelet Considerations
Plasma Considerations
Ordering Practices
Serologic Versus Computer Crossmatch
Emerging Infections
Arboviruses
Babesia Species
Creutzfeldt-Jakob Disease (CJD)
Pathogen Reduction Technology (PRT)
Conclusion
References
3: Blood Component Therapy
Introduction
PRBCs
Fresh Frozen Plasma
Platelets
Cryoprecipitate
References

4: The Coagulation System and Blood Clot Stability
Introduction
Coagulation Factors and Their Functions
Normal Coagulation Cascade
Regulation of Coagulation
Mechanisms of Clot Stability and Fibrinolysis
Factors Affecting Clot Stability
Fibrinolysis: Regulation and Its Role in Disease Process
Summary
References
5: Fibrinolysis, Antifibrinolytic Agents, and Perioperative Considerations
Introduction
Fibrinolysis and Molecular Regulation
Measuring Fibrinolysis
Antifibrinolytic Agents
Tranexamic Acid
Epsilon-Aminocaproic Acid
Aprotinin

Perioperative Considerations
Cardiac Surgery
Tranexamic Acid and the Risk of Seizures
Trauma, the Role of Fibrinolysis, and Traumatic Brain Injury
Orthopedics
Liver Surgery and Transplantation
Obstetrics
Subarachnoid Hemorrhage
Pediatrics
Topical Tranexamic Acid
Conclusions
References
6: Hypercoagulation and Thrombotic Disorders
Introduction
Hypercoagulable States
Primary (Congenital) Hypercoagulable States
Antithrombin Deficiency
Protein C and S Deficiency
Factor V Leiden (Activated Protein C Resistance)
Hyperhomocysteinemia

Other Primary Hypercoagulable States
Secondary (Acquired) Hypercoagulable States
Pregnancy/Puerperium
Oral Contraceptives and Hormone Replacement Therapy
Antiphospholipid Syndrome
Other Secondary Hypercoagulable States
Summary
References
7: Diseases or Conditions of Platelet Disorders
Introduction
Types of Disorders
Thrombocytopenia
Thrombocythemia and Thrombocytosis
Inherited Platelet Disorders
Diagnosis
Management
Desmopressin
Platelet Concentrates
Recombinant Activated Factor VII (rFVIIa)
Antifibrinolytics
Hormonal Therapy

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