Exploration of host genetic factors associated with malaria / by Tabish Qidwai.
Qidwai, Tabish, author.
2021
RC157 .Q53 2021
Available Online

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Title Exploration of host genetic factors associated with malaria / by Tabish Qidwai.
Author Qidwai, Tabish, author.
ISBN 9789813347618
9813347619
9789813347601
9813347600
DOI https://doi.org/10.1007/978-981-33-4761-8
Published Singapore : Springer, [2021]
Language English
Description 1 online resource (xi, 172 pages) : illustrations.
Other Standard Identifiers 10.1007/978-981-33-4761-8 doi
Call Number RC157 .Q53 2021
Dewey Decimal Classification 611.01816
599.935
Summary "This book is aimed to cover the role of genetic polymorphisms in human genes related to RBC disorders, metabolic enzymes, immune response, and cytoadherence in the susceptibility/resistance to malaria caused by Plasmodium falciparum. The chapters provide current information on the balancing trait and the significance of such traits in the malaria resistance. The book covers polymorphisms in the genes of the red blood cells-sickle cell anaemia; glucose-6-phosphate dehydrogenase deficiency and thalassemia that confer protection against malaria. In addition, the book explores selection of genetic variations in the human genome as genetic control mechanism against malaria in endemic regions. It also provides a comprehensive overview of the molecular epidemiology and natural selection of alleles in the genes which are associated with malaria, and presents description of the role of human genetic polymorphisms in malaria disease risk and disease outcome."-- Provided by publisher.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Digital File Characteristics text file PDF
Available in Other Form Print version: 9789813347601
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Chapter 1. Human genetics and infectious disease
Part 1. RBC disorders
Chapter 2. Sickle cell gene
Chapter 3. Alpha-Thalassemia
Chapter 4. Beta-Thalassemia
Chapter 5. Duffy blood group locus
Part 2. Metabolic enzymes
Chapter 6. Pyruvate kinase deficiency
Chapter 7. Glucose 6-Phosphate dehydrogenase
Part 3. Host immune response
Chapter 8. TNF genetic polymorphisms
Chapter 9. iNos genetic polymorphisms
Chapter 10. Human complement receptor 1 polymorphisms
Chapter 11. Interferonalpha receptor-1 (IFNAR1) polymorphisms
Part 4. Cytoadherence
Chapter 12. Intercellular adhesion molecule-1 polymorphisms
Chapter 13. Platelet endothelial cell adhesion molecule-1 (PECAM-1) polymorphisms
Chapter 14. Vascular cell adhesion molecule-1 (VCAM1) polymorphisms.

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