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001435499 020__ $$a9789813366794$$q(electronic bk.)
001435499 020__ $$a9813366796$$q(electronic bk.)
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001435499 0247_ $$a10.1007/978-981-33-6679-4$$2doi
001435499 035__ $$aSP(OCoLC)1244624471
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001435499 049__ $$aISEA
001435499 050_4 $$aRC388.5
001435499 08204 $$a616.8/1$$223
001435499 24500 $$aModels and techniques in stroke biology /$$cAmit Kumar Tripathi, Abhishek Kumar Singh, editors.
001435499 260__ $$aSingapore :$$bSpringer,$$c2021.
001435499 300__ $$a1 online resource (116 pages)
001435499 336__ $$atext$$btxt$$2rdacontent
001435499 337__ $$acomputer$$bc$$2rdamedia
001435499 338__ $$aonline resource$$bcr$$2rdacarrier
001435499 347__ $$atext file
001435499 347__ $$bPDF
001435499 500__ $$aChapter 4: A Non-human Primate Model for Cerebral Stroke.
001435499 504__ $$aIncludes bibliographical references.
001435499 5050_ $$aIntro -- Contents -- About the Editors -- Chapter 1: Rodent Stroke Model Guidelines: An Update -- 1.1 Introduction -- 1.2 The General Guideline for a Rodent Model for Stroke -- 1.3 STAIR Committee, Recommendations, and Guidelines -- 1.4 Intraluminal Model -- 1.5 Different Types of the Occluder and their Success Rate -- 1.6 PLL-Coated Occluders -- 1.7 Flame Blunted Occluders -- 1.8 Silicone-Rubber Coated Occluders -- 1.9 An Optimization Technique for Intraluminal Inserting Occluders -- 1.10 Optimization of Surgical Procedure -- 1.11 The Tamura Method of a Stroke Model
001435499 5058_ $$a1.12 Infarction Area Estimation -- 1.13 Methods for Infarction Visualization -- 1.14 Direct Image of Infarction in Fresh Brain Sections Stained with TTC Solution -- 1.15 Digital Method for Defining the Infarction -- 1.16 Calculation of Infarction Volume -- 1.17 Preparation of Stroke Surgical Procedure -- 1.18 Koizumiś Suture Method -- 1.19 Longaś MCAO Method -- 1.20 Neurobehaviour Assessment of Functional Recovery -- 1.21 Assessment of Neurological Functional Outcomes -- 1.21.1 Composite Score -- 1.21.1.1 Bederson Scale and Neurological Deficit Scoring
001435499 5058_ $$a1.21.1.2 Modified Neurological Severity Score -- 1.21.2 Motor Tests -- 1.21.2.1 Cylinder Test -- 1.21.2.2 Ledged Tapered Beam Test -- 1.21.2.3 Pellet Retrieval Task -- 1.21.3 Sensorimotor Test -- 1.21.3.1 Forelimb Flexion -- 1.21.3.2 Forelimb Placing -- 1.21.3.3 Accelerated Rotarod Test -- 1.21.3.4 Adhesive Removal Test -- 1.22 Anesthetics -- 1.23 Monitoring and Maintaining the Core Brain Temperature -- 1.24 Mechanical Ventilation, Blood Gases, Glucose, and Blood Pressure Monitoring -- 1.25 Pilot Study Plan and Implementation of a Preclinical Stroke Trial
001435499 5058_ $$a1.26 Application of the Suitable Statistical Method for Data Analysis -- 1.27 Standard Operating Procedures for Creating a Stroke Model -- 1.28 Conclusion and Future Direction -- References -- Chapter 2: Bilateral Common Carotid Artery Occlusion: Stroke Model -- 2.1 Introduction -- 2.2 Importance of BCCAO -- 2.3 Permanent BCCAO -- 2.4 Transient BCCAO -- 2.5 BCCAO Sham Surgery -- 2.6 Factors Affecting the BCCAO -- 2.6.1 Effect of Ischemic Preconditioning -- 2.7 Effect of ROS -- 2.8 Effect of Mitochondrial Dysfunction -- 2.9 Role of the Apoptotic Pathway
001435499 5058_ $$a2.10 Effect of BCCAO Duration and Animal Model Sex -- 2.11 Effect on Blood-Brain Barrier -- 2.12 Effect of Oxygen Free Radicals -- 2.13 Conclusion -- References -- Chapter 3: Cerebral Venous Sinus Thrombosis Rodent Model -- 3.1 Introduction -- 3.2 Clinical Manifestation, Diagnosis, and Prognosis of CVST -- 3.3 Clinical Recommendation for Management of CVST Patients -- 3.4 Experimental CVST Model Protocol -- 3.5 Precautions -- 3.6 TTC Staining Technique -- 3.7 Neurological Evaluation -- 3.8 CVST as a Preclinical Model for Evaluation of Neuroprotective Agents -- References
001435499 506__ $$aAccess limited to authorized users.
001435499 520__ $$aThis book summarizes various tools and techniques used to provide insights into the cellular and molecular pathophysiology of stroke. It also presents rodent animal models to help shed light on the pathophysiology of ischemic stroke. Presenting the latest information on the different types of stroke, including embolic, filament, photothrombotic, and bilateral common carotid artery, the book also describes techniques that are used for confirmation of stroke surgery, such as laser speckle imaging (LSI) and laser Doppler flowmetry (LDF), and discusses the non-human primates that are used in stroke surgery, cerebral venous sinuous thrombosis, and neurobehavioral assessment. Lastly, it analyzes various neuroprotective agents to treat and prevent ischemic stroke, and examines the challenges and advances in treating and preventing acute ischemic stroke.
001435499 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed April 22, 2021).
001435499 650_0 $$aCerebrovascular disease$$xSimulation methods.
001435499 650_6 $$aAccidents vasculaires cérébraux$$xMéthodes de simulation.
001435499 655_0 $$aElectronic books.
001435499 7001_ $$aTripathi, Amit Kumar.
001435499 7001_ $$aSingh, Abhishek Kumar.
001435499 77608 $$iPrint version:$$aTripathi, Amit Kumar.$$tModels and Techniques in Stroke Biology.$$dSingapore : Springer Singapore Pte. Limited, ©2021$$z9789813366787
001435499 852__ $$bebk
001435499 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-33-6679-4$$zOnline Access$$91397441.1
001435499 909CO $$ooai:library.usi.edu:1435499$$pGLOBAL_SET
001435499 980__ $$aBIB
001435499 980__ $$aEBOOK
001435499 982__ $$aEbook
001435499 983__ $$aOnline
001435499 994__ $$a92$$bISE