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001435528 001__ 1435528
001435528 003__ OCoLC
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001435528 019__ $$a1244536279$$a1253415995
001435528 020__ $$a9783030671716$$q(electronic bk.)
001435528 020__ $$a3030671712$$q(electronic bk.)
001435528 020__ $$a9783030671723$$q(print)
001435528 020__ $$a3030671720
001435528 020__ $$a9783030671730$$q(print)
001435528 020__ $$a3030671739
001435528 020__ $$z9783030671709$$q(print)
001435528 020__ $$z3030671704
001435528 0247_ $$a10.1007/978-3-030-67171-6$$2doi
001435528 035__ $$aSP(OCoLC)1244629573
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001435528 049__ $$aISEA
001435528 050_4 $$aQH603.E93
001435528 08204 $$a571.5$$223
001435528 24500 $$aNew frontiers :$$bextracellular vesicles /$$cSuresh Mathivanan, Pamali Fonseka, Christina Nedeva, Ishara Atukorala, editors.
001435528 260__ $$aCham :$$bSpringer,$$c2021.
001435528 300__ $$a1 online resource (539 pages)
001435528 336__ $$atext$$btxt$$2rdacontent
001435528 337__ $$acomputer$$bc$$2rdamedia
001435528 338__ $$aonline resource$$bcr$$2rdacarrier
001435528 347__ $$atext file
001435528 347__ $$bPDF
001435528 4901_ $$aSubcellular Biochemistry ;$$vv. 97
001435528 500__ $$aPathogen-Derived BMVs Can Modulate the Host Immune Response.
001435528 500__ $$aIncludes index.
001435528 5050_ $$aIntro -- Preface -- EVs: A Diverse Community -- Functional Role and Clinical Implications of EVs -- Contents -- About the Editors -- Part I: Subtypes, Biogenesis, and Secretion of Extracellular Vesicles -- Chapter 1: Introduction to the Community of Extracellular Vesicles -- Introduction -- Subtypes of EVs -- Molecular Composition of EVs -- Isolation and Characterisation of EVs -- Concluding Remarks -- References -- Chapter 2: Biogenesis of Extracellular Vesicles -- Introduction: Extracellular Vesicles -- Large Oncosomes -- Apoptotic Bodies -- Migrasomes -- Ectosomes/Shedding Microvesicles
001435528 5058_ $$aExosomes -- ESCRT-Dependent Pathway of ILV Biogenesis -- ESCRT-Independent Pathway of ILV Biogenesis -- Role of Tetraspanins in Biogenesis of Exosomes -- Secretion of Exosomes -- Exomeres -- Concluding Remarks -- References -- Chapter 3: The Role of Post-Translational Modifications in Targeting Protein Cargo to Extracellular Vesicles -- Introduction -- Phosphorylation -- Glycosylation -- Ubiquitination -- SUMOylation -- Oxidation -- Citrullination -- ISGylation -- Myristoylation -- Palmitoylation -- Concluding Remarks -- References
001435528 5058_ $$aChapter 4: Apoptotic Bodies: Mechanism of Formation, Isolation and Functional Relevance -- Introduction -- Mechanisms of Apoptotic Cell Disassembly -- Step 1: Plasma Membrane Blebbing -- Step 2: Apoptotic Membrane Protrusion Formation -- Pannexin 1 -- Plexin B2 -- Cytoskeleton -- Vesicle Trafficking -- Step 3: ApoBD Fragmentation -- Maintenance of Plasma Membrane Integrity to Prevent Premature Lysis -- Methods of ApoBD Isolation -- Differential Centrifugation -- Filtration -- Fluorescence-Activated Cell Sorting (FACS) -- Validation of ApoBDs -- Functional Significance of ApoBD Formation
001435528 5058_ $$aApoBDs in Cell Clearance -- ApoBDs in Intercellular Communication -- Intercellular Communication Through DNA as Cargos -- Intercellular Communication Through RNA as Cargos -- Intercellular Communication Through Proteins as Cargos -- Intercellular Communication Through Pathogen-Derived Material -- Concluding Remarks -- References -- Chapter 5: Exomeres: A New Member of Extracellular Vesicles Family -- Introduction -- Exomeres -- Proteomic Cargo of Exomeres -- Isolation of Exomeres -- Concluding Remarks -- References -- Part II: Functional Role and Clinical Implications of Extracellular Vesicles
001435528 5058_ $$aChapter 6: Pathogenesis Mediated by Bacterial Membrane Vesicles -- Introduction -- What are Bacterial Membrane Vesicles? -- The Study of BMVs -- Isolation and Purification -- Characterisation & Analysis -- BMV Biogenesis -- Mechanisms of OMV Biogenesis -- Mechanisms of MV Biogenesis -- Cargo Packaging into BMVs -- Physiological Roles of BMVs -- Physiological Roles of OMVs Produced by Gram-Negative Bacteria -- Biofilm Formation -- Nutrient Acquisition -- Competition and Predation -- Bacterial Defence -- Horizontal Gene Transfer -- Physiological Roles of MVs Produced by Gram-Positive Bacteria
001435528 506__ $$aAccess limited to authorized users.
001435528 520__ $$aThe field of extracellular vesicles (EVs) has progressed immensely in recent times with evidences highlighting their importance in physiology and pathology. This book entails extensive reflective literature on many subtypes of EVs including exosomes, exomeres, ectosomes, apoptotic vesicles, bacterial EVs and fungal EVs. The book further discusses the biogenesis and secretion of these EVs, detailing the biological pathways and proteins involved. Research investigating the biological functions of EVs is rapidly increasing and the current knowledge around their role in progression of diseases such as cancer, neurodegeneration and metabolic disorders is discussed in multiple chapters. The implications of EVs in intercellular communication and the significance of biologically active cargo carried within these EVs are further examined. Moreover, the numerous applications of EVs in diagnostics and treatment of diseases are reviewed in detail, particularly their potential as biomarkers and drug delivery vehicles. Taken together, this book is a compilation of the key implications of EVs that are secreted by virtually all cell types. Readers will gain a perspective into the biology, functions and applications of EVs and their constantly evolving knowledge base.
001435528 588__ $$aDescription based on print version record.
001435528 650_0 $$aExtracellular space.
001435528 650_0 $$aCell organelles.
001435528 650_6 $$aEspace extracellulaire.
001435528 655_0 $$aElectronic books.
001435528 7001_ $$aMathivanan, Suresh.
001435528 7001_ $$aFonseka, Pamali.
001435528 7001_ $$aNedeva, Christina.
001435528 7001_ $$aAtukorala, Ishara.
001435528 77608 $$iPrint version:$$aMathivanan, Suresh.$$tNew Frontiers: Extracellular Vesicles.$$dCham : Springer International Publishing AG, ©2021$$z9783030671709
001435528 830_0 $$aSub-cellular biochemistry ;$$vv. 97.
001435528 852__ $$bebk
001435528 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-67171-6$$zOnline Access$$91397441.1
001435528 909CO $$ooai:library.usi.edu:1435528$$pGLOBAL_SET
001435528 980__ $$aBIB
001435528 980__ $$aEBOOK
001435528 982__ $$aEbook
001435528 983__ $$aOnline
001435528 994__ $$a92$$bISE