New frontiers : extracellular vesicles / Suresh Mathivanan, Pamali Fonseka, Christina Nedeva, Ishara Atukorala, editors.
Mathivanan, Suresh.; Fonseka, Pamali.; Nedeva, Christina.; Atukorala, Ishara.
2021
QH603.E93
Available Online

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Title
New frontiers : extracellular vesicles / Suresh Mathivanan, Pamali Fonseka, Christina Nedeva, Ishara Atukorala, editors.
ISBN
9783030671716 (electronic bk.)
3030671712 (electronic bk.)
9783030671723 (print)
3030671720
9783030671730 (print)
3030671739
9783030671709 (print)
3030671704
DOI
https://doi.org/10.1007/978-3-030-67171-6
Publication Details
Cham : Springer, 2021.
Language
English
Description
1 online resource (539 pages)
Item Number
10.1007/978-3-030-67171-6 doi
Call Number
QH603.E93
Dewey Decimal Classification
571.5
Summary
The field of extracellular vesicles (EVs) has progressed immensely in recent times with evidences highlighting their importance in physiology and pathology. This book entails extensive reflective literature on many subtypes of EVs including exosomes, exomeres, ectosomes, apoptotic vesicles, bacterial EVs and fungal EVs. The book further discusses the biogenesis and secretion of these EVs, detailing the biological pathways and proteins involved. Research investigating the biological functions of EVs is rapidly increasing and the current knowledge around their role in progression of diseases such as cancer, neurodegeneration and metabolic disorders is discussed in multiple chapters. The implications of EVs in intercellular communication and the significance of biologically active cargo carried within these EVs are further examined. Moreover, the numerous applications of EVs in diagnostics and treatment of diseases are reviewed in detail, particularly their potential as biomarkers and drug delivery vehicles. Taken together, this book is a compilation of the key implications of EVs that are secreted by virtually all cell types. Readers will gain a perspective into the biology, functions and applications of EVs and their constantly evolving knowledge base.
Note
Pathogen-Derived BMVs Can Modulate the Host Immune Response.
Includes index.
Access Note
Access limited to authorized users.
Digital File Characteristics
text file
PDF
Source of Description
Description based on print version record.
Added Author
Mathivanan, Suresh.
Fonseka, Pamali.
Nedeva, Christina.
Atukorala, Ishara.
Series
Sub-cellular biochemistry ; v. 97.
Available in Other Form
New Frontiers: Extracellular Vesicles.
Linked Resources
Online Access
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Intro
Preface
EVs: A Diverse Community
Functional Role and Clinical Implications of EVs
Contents
About the Editors
Part I: Subtypes, Biogenesis, and Secretion of Extracellular Vesicles
Chapter 1: Introduction to the Community of Extracellular Vesicles
Introduction
Subtypes of EVs
Molecular Composition of EVs
Isolation and Characterisation of EVs
Concluding Remarks
References
Chapter 2: Biogenesis of Extracellular Vesicles
Introduction: Extracellular Vesicles
Large Oncosomes
Apoptotic Bodies
Migrasomes
Ectosomes/Shedding Microvesicles

Exosomes
ESCRT-Dependent Pathway of ILV Biogenesis
ESCRT-Independent Pathway of ILV Biogenesis
Role of Tetraspanins in Biogenesis of Exosomes
Secretion of Exosomes
Exomeres
Concluding Remarks
References
Chapter 3: The Role of Post-Translational Modifications in Targeting Protein Cargo to Extracellular Vesicles
Introduction
Phosphorylation
Glycosylation
Ubiquitination
SUMOylation
Oxidation
Citrullination
ISGylation
Myristoylation
Palmitoylation
Concluding Remarks
References

Chapter 4: Apoptotic Bodies: Mechanism of Formation, Isolation and Functional Relevance
Introduction
Mechanisms of Apoptotic Cell Disassembly
Step 1: Plasma Membrane Blebbing
Step 2: Apoptotic Membrane Protrusion Formation
Pannexin 1
Plexin B2
Cytoskeleton
Vesicle Trafficking
Step 3: ApoBD Fragmentation
Maintenance of Plasma Membrane Integrity to Prevent Premature Lysis
Methods of ApoBD Isolation
Differential Centrifugation
Filtration
Fluorescence-Activated Cell Sorting (FACS)
Validation of ApoBDs
Functional Significance of ApoBD Formation

ApoBDs in Cell Clearance
ApoBDs in Intercellular Communication
Intercellular Communication Through DNA as Cargos
Intercellular Communication Through RNA as Cargos
Intercellular Communication Through Proteins as Cargos
Intercellular Communication Through Pathogen-Derived Material
Concluding Remarks
References
Chapter 5: Exomeres: A New Member of Extracellular Vesicles Family
Introduction
Exomeres
Proteomic Cargo of Exomeres
Isolation of Exomeres
Concluding Remarks
References
Part II: Functional Role and Clinical Implications of Extracellular Vesicles

Chapter 6: Pathogenesis Mediated by Bacterial Membrane Vesicles
Introduction
What are Bacterial Membrane Vesicles?
The Study of BMVs
Isolation and Purification
Characterisation & Analysis
BMV Biogenesis
Mechanisms of OMV Biogenesis
Mechanisms of MV Biogenesis
Cargo Packaging into BMVs
Physiological Roles of BMVs
Physiological Roles of OMVs Produced by Gram-Negative Bacteria
Biofilm Formation
Nutrient Acquisition
Competition and Predation
Bacterial Defence
Horizontal Gene Transfer
Physiological Roles of MVs Produced by Gram-Positive Bacteria

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