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001435578 001__ 1435578
001435578 003__ OCoLC
001435578 005__ 20230309003901.0
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001435578 007__ cr\un\nnnunnun
001435578 008__ 210408s2021\\\\si\\\\\\ob\\\\001\0\eng\d
001435578 019__ $$a1245670622
001435578 020__ $$a9789811609992$$q(electronic bk.)
001435578 020__ $$a9811609993$$q(electronic bk.)
001435578 020__ $$z9789811609985
001435578 020__ $$z9811609985
001435578 0247_ $$a10.1007/978-981-16-0999-2$$2doi
001435578 035__ $$aSP(OCoLC)1245473396
001435578 040__ $$aYDX$$beng$$erda$$epn$$cYDX$$dGW5XE$$dOCLCO$$dEBLCP$$dN$T$$dUKAHL$$dOCLCQ$$dCOM$$dOCLCQ
001435578 049__ $$aISEA
001435578 050_4 $$aRM409
001435578 08204 $$a615.7/922$$223
001435578 1001_ $$aBremner, John,$$eauthor.
001435578 24510 $$aMultiple action-based design approaches to antibacterials /$$cJohn Bremner.
001435578 264_1 $$aSingapore :$$bSpringer,$$c[2021]
001435578 300__ $$a1 online resource
001435578 336__ $$atext$$btxt$$2rdacontent
001435578 337__ $$acomputer$$bc$$2rdamedia
001435578 338__ $$aonline resource$$bcr$$2rdacarrier
001435578 504__ $$aIncludes bibliographical references and index.
001435578 5050_ $$aIntro -- Preface -- Contents -- About the Author -- 1 Antibacterials -- 1.1 Bacteria -- 1.2 Antibacterial Action -- 1.3 Bacterial Resistance to Antibacterials -- 1.3.1 Introduction to Key Resistance Mechanisms -- 1.3.2 Resistance and Resilience -- 1.3.3 The Gram-Negative Challenge -- 1.3.4 Other Survival Strategies -- 1.4 Approaches to Meeting Needs -- 1.5 Ways to Achieve Multi-action Effects -- 1.6 Bacterial Over Host Selectivity -- References -- 2 Antibacterial Combinations -- 2.1 Introduction -- 2.1.1 Dual Combinations Resulting in Two Actions
001435578 5058_ $$a2.1.2 Dual Combinations Resulting in Three or More Actions -- 2.1.3 Triple Combinations Resulting in Three or More Actions -- 2.1.4 Quadruple Combinations with Four or More Actions -- 2.1.5 Pentuple Combinations -- 2.2 Summary -- References -- 3 Single Molecule Non-cleavable Multiply Active Antibacterials -- 3.1 Introduction to General Design Considerations -- 3.1.1 General Approaches to Hybrids -- 3.1.2 Factors in Antibacterial Hybrid Design -- 3.2 Designing for Mainly Dual Activity -- 3.2.1 Dual Action Antibacterial Hybrids -- 3.2.2 Examples of Dual Action Agents from Nature
001435578 5058_ $$a3.2.3 Berberine as a Starting Point for Design -- 3.3 Triple Action Antibacterial Hybrid Agents -- 3.3.1 General Points -- 3.3.2 Potential Design Based on Pharmacophoric Elements -- 3.3.3 Established and Potential Single Molecule Triple Action or Interaction Agents -- 3.3.4 Designing Potential New Non-cleavable Triple Action Agents -- 3.4 More Than Triple Action Hybrid Agents -- References -- 4 Design Principles and Development of Prodrugs for Multiply Active Antibacterials -- 4.1 Definitions -- 4.1.1 Carrier-Linked Prodrugs (Carrier Prodrugs) -- 4.1.2 Bioprecursor Prodrugs
001435578 5058_ $$a4.2 Introduction to Prodrugs for Triple or Higher Action Antibacterials -- 4.2.1 Design Considerations -- 4.2.2 Classification and Examples of Cleavable Types for Triple or Higher Action -- 4.2.3 Cleavable Type I -- 4.2.4 Cleavable Type II -- 4.2.5 Cleavable Type III -- 4.2.6 Cleavable Type IV -- 4.3 Release Mechanisms and Prodrug Design -- 4.3.1 Biological -- 4.3.2 Chemical -- 4.3.3 Physical -- 4.4 Metabolism Activated Multi-targeting -- 4.5 Conclusion -- References -- 5 Future Possibilities -- 5.1 Introduction
001435578 5058_ $$a5.2 New Combinations and Single Molecules with Multi-activity Development Potential -- 5.2.1 Combinations -- 5.2.2 Hybrid Molecule Possibibilities -- 5.3 Search for Different Chemical Structure Types -- 5.3.1 In Silico Advances -- 5.4 New Modes of Action/New Targets -- 5.5 DNA and RNA Level Modulation -- 5.6 Proteins and Antibacterials -- 5.7 Concluding Remarks -- References -- Index
001435578 506__ $$aAccess limited to authorized users.
001435578 520__ $$aThis book covers intentional design aspects for combinations of drugs, single-molecule hybrids with potential or actual multiple actions, pro-drugs which could yield multiple activity outcomes, and future possibilities. The approach of the book is interdisciplinary, and it provides greater understanding of the complex interplay of factors involved in the medicinal chemistry design and laboratory development of multiply active antibacterials. The scope of the book appeals to readers who are researching in the field of antibacterials using the approach of medicinal chemistry design and drug development.
001435578 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed April 14, 2021).
001435578 650_0 $$aAntibacterial agents$$xDesign.
001435578 655_0 $$aElectronic books.
001435578 77608 $$iPrint version:$$z9811609985$$z9789811609985$$w(OCoLC)1237632481
001435578 852__ $$bebk
001435578 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-16-0999-2$$zOnline Access$$91397441.1
001435578 909CO $$ooai:library.usi.edu:1435578$$pGLOBAL_SET
001435578 980__ $$aBIB
001435578 980__ $$aEBOOK
001435578 982__ $$aEbook
001435578 983__ $$aOnline
001435578 994__ $$a92$$bISE