@article{1435607, author = {Kinghorn, A. Douglas. and Falk, Heinz, and Gibbons, Simon and Asakawa, Yoshinori. and Liu, Ji-Kai. and Dirsch, Verena M.}, url = {http://library.usi.edu/record/1435607}, title = {Progress in the chemistry of organic natural products., Volume 115 /}, abstract = {This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.}, doi = {https://doi.org/10.1007/978-3-030-64853-4}, recid = {1435607}, pages = {1 online resource (210 pages)}, }