TY  - GEN
N2  - This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.
DO  - 10.1007/978-3-030-64853-4
DO  - doi
AB  - This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.
T1  - Progress in the chemistry of organic natural products.
AU  - Kinghorn, A. Douglas.
AU  - Falk, Heinz,
AU  - Gibbons, Simon
AU  - Asakawa, Yoshinori.
AU  - Liu, Ji-Kai.
AU  - Dirsch, Verena M.
VL  - v. 115
CN  - QD251
ID  - 1435607
KW  - Chemistry, Organic.
KW  - Pharmaceutical chemistry.
KW  - Clinical biochemistry.
KW  - Chimie organique.
KW  - Chimie pharmaceutique.
KW  - Biochimie clinique.
SN  - 9783030648534
SN  - 3030648532
TI  - Progress in the chemistry of organic natural products.
LK  - https://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-64853-4
UR  - https://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-64853-4
ER  -