Intro
Series Preface
Volume Preface
Contents
Part I: Glial-Neuronal Interactions in the Control of Hypothalamic Development
1: The Role of Microglia in the Developing Hypothalamus
1.1 Introduction
1.1.1 Hypothalamic Organization and Function in the Neuroendocrine System
1.1.2 Microglia Invasion During Hypothalamic Development
1.1.3 Hypothalamic Gliogenesis
1.2 Unraveling Hematopoiesis and the Unique Origins of Microglia
1.2.1 Hematopoiesis
1.2.2 Microglial Origins
1.2.3 Border-Associated Macrophages

1.3 Local Environmental Signals Shape Microglia Development and Influence Microglial Heterogeneity
1.3.1 Microglial Heterogeneity
Box 1.1: Single-Cell RNA Sequencing
1.4 Microglial Functions During Hypothalamic Development
1.4.1 Importance of Embryonic Microglia for the Proper Development of Hypothalamic Circuitry
Box 1.2: Using CSF1R Inhibitors to Deplete Microglia in the CNS
Box 1.3: Hypothalamic Circuitry Involved in Feeding and Energy Balance
1.5 Microglia Are Sexually Dimorphic and Contribute to Sexual Dimorphism Within the Hypothalamus

1.5.1 A Role for Microglia in the Establishment of Sexually Dimorphic Brain Regions
1.6 Embryonic Microglia Act as Sensors During Development
1.7 Perspectives
1.8 Key Literature
References
Part II: Glial-Neuronal Interactions in the Control of the Magnocellular Neuroendocrine System
2: Functional Consequences of Morphological Plasticity in the Adult Hypothalamo-Neurohypophysial System
2.1 Introduction: Structural Glial Plasticity in the Adult HNS
2.1.1 Anatomy of the HNS System
2.1.2 Functions of Oxytocin and Vasopressin

2.1.3 Electrophysiology of Oxytocin and Vasopressin Neurons
2.1.4 Glial Cells of the HNS
2.1.5 Structural Glial Plasticity in the Adult HNS
2.1.6 Investigating the Functional Consequences of Structural Plasticity
2.2 Contribution of the Astrocytic Environment to Homosynaptic Strength
Box 2.1: Investigating the Presynaptic Origin of Drug Action Using Paired-Pulse Facilitation
2.2.1 Role of Glutamate Uptake on Homosynaptic Efficacy
2.2.2 Control of Homosynaptic Efficacy Through Metabotropic Glutamate Receptors
2.2.3 Glial Coverage Controls Homosynaptic Efficacy

2.2.4 Glial Coverage Controls Concentration and/or Time Course in the Synaptic Cleft
2.2.5 Physiological Consequences
2.3 Contribution of the Astrocytic Environment to Inter-synaptic Crosstalk
2.3.1 Glial Coverage Controls Diffusion in the Extracellular Space
2.3.2 Changes in Diffusion Facilitate Heterosynaptic Activity Through Metabotropic Glutamate Receptors
2.3.3 Limiting Changes in Diffusion Affect Glutamate Spillover
2.3.4 Functional Presynaptic Kainate Receptors on GABAergic Terminals in the HNS