Intro
Preface
Contents
Contributors
About the Editor
Chapter 1: Signaling Pathways of Hyperhomocystenemia and Oxidative Stress
1 Introduction
2 Cofactors for Re-Methylation and Trans-Sulfuration Pathways
2.1 Folate
2.2 Vitamin B12
2.3 Vitamin B6
3 Hyperhomocysteinemia and Oxidative Stress
4 Conclusion
References
Chapter 2: Hyperhomocysteinemia and Cancer: The Role of Natural Products and Nutritional Interventions
1 Introduction
2 Biosynthesis of Homocysteine
3 Metabolism of Homocysteine
3.1 Remethylation
3.2 Transsulfuration

4 Hyperhomocysteinemia Induction
4.1 Genetic Enzymatic Defects
4.2 Absence/Inadequate Amounts of Certain Cofactors
4.3 Excessive Methionine Consumption
5 Diseases Associated with Hyperhomocysteinemia
5.1 Chronic Renal Failure
5.2 Hypothyroidism
5.3 Anemia
5.4 Malignant Tumors
5.5 Medications
6 Hyperhomocysteinemia and Cancer
7 Hyperhomocysteinemia Management Using Natural Products and Diet
8 Conclusion
References
Chapter 3: Anti-inflammatory Role of Anthocyanins in the Prevention of Hyperhomocysteinemia-Mediated Cardiometabolic Diseases
1 Introduction

2 Inflammation
3 Inflammation and Hyperhomocysteinemia
4 Cardiometabolic Diseases and Plant Polyphenols
5 Homocysteine and Anthocyanins
6 Anthocyanins: The Treasure of Health
6.1 Chemical Structure and Chemistry of Anthocyanins
6.2 Anthocyanin and Inflammation
7 Conclusion
References
Chapter 4: Metabolic Role of Hyperhomocysteinemia in the Etiology of Chronic Diseases
1 Introduction
2 Homocysteine Metabolism
3 Hyperhomocysteinemia and Neurological Disorders
3.1 Stroke
3.2 Mild Cognitive Impairment (MCI), and Dementia
3.3 Parkinson's Disease (PD)

3.4 Epilepsy
4 Hyperhomocysteinemia and Cardiovascular Diseases
5 Hyperhomocysteinemia and Cancer
6 Conclusion
References
Chapter 5: B-Vitamins Attenuates Preliminary Steps of Hyperhomocysteinemia and Colorectal Cancer
1 Introduction
2 Dietary and Non-dietary Risk Factors for Colorectal Cancer
3 B-Vitamins, Glutathione and Colorectal Cancer
4 Hyperhomocysteinemia and Colorectal Cancer
5 Conclusion
References
Chapter 6: Hyperhomocysteinemia, B-Vitamins, and Coronary Artery Disease Risk
1 Introduction

2 Sulfur Metabolism and Pathogenesis of Coronary Artery Disease
3 Hyperhomocysteinemia and Coronary Artery Disease
4 B-Vitamins Therapy and CAD
5 Conclusion
References
Chapter 7: Potential Role of Hyperhomocysteinemia in Prediabetes Etiology and Pathology
1 Introduction
2 B-vitamins, Oxidative Stress and Prediabetes Risk
3 Hyperhomocysteinemia and the Pathogenesis of Prediabetes and Type 2 Diabetes
4 Current Research
5 Conclusion
References
Chapter 8: Genetic Risk Factors in the Development of Hyperhomocysteinemia
1 Introduction