001436499 000__ 04883cam\a2200589\i\4500
001436499 001__ 1436499
001436499 003__ OCoLC
001436499 005__ 20230309004030.0
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001436499 008__ 210511s2021\\\\sz\a\\\\ob\\\\000\0\eng\d
001436499 019__ $$a1250307417
001436499 020__ $$a9783030658175$$q(electronic bk.)
001436499 020__ $$a3030658171$$q(electronic bk.)
001436499 020__ $$z9783030658168$$q(print)
001436499 020__ $$z3030658163
001436499 0247_ $$a10.1007/978-3-030-65817-5$$2doi
001436499 035__ $$aSP(OCoLC)1250313038
001436499 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dYDX$$dOCLCO$$dEBLCP$$dOCLCF$$dOCLCO$$dCNO$$dUKAHL$$dOCLCQ$$dCOM$$dOCLCO$$dOCLCQ
001436499 049__ $$aISEA
001436499 050_4 $$aQP88.45
001436499 08204 $$a616.02/774$$223
001436499 1001_ $$aBrouns, Inge,$$eauthor.
001436499 24514 $$aThe pulmonary neuroepithelial body microenvironment :$$ba multifunctional unit in the airway epithelium /$$cInge Brouns, Line Verckist, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen.
001436499 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2021]
001436499 300__ $$a1 online resource (xviii, 99 pages) :$$billustrations (some color)
001436499 336__ $$atext$$btxt$$2rdacontent
001436499 337__ $$acomputer$$bc$$2rdamedia
001436499 338__ $$aonline resource$$bcr$$2rdacarrier
001436499 4901_ $$aAdvances in anatomy, embryology and cell biology,$$x0301-5556 ;$$v233
001436499 504__ $$aIncludes bibliographical references.
001436499 5050_ $$aPulmonary sensory receptors -- The pulmonary NEB ME is a complex intraepithelial unit -- Studying the pulmonary NEB ME: a multidisciplinary approach -- Functional exploration of the pulmonary NEB ME -- Concluding remarks and future perspectives -- References -- ADDENDUM.
001436499 506__ $$aAccess limited to authorized users.
001436499 520__ $$aThis monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors.
001436499 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed May 11, 2021).
001436499 650_0 $$aPulmonary endothelium$$xMolecular aspects.
001436499 650_0 $$aStem cells.
001436499 650_6 $$aEndothélium pulmonaire$$xAspect moléculaire.
001436499 650_6 $$aCellules souches.
001436499 655_0 $$aElectronic books.
001436499 7001_ $$aVerckist, Line,$$eauthor.
001436499 7001_ $$aPintelon, Isabel,$$eauthor.
001436499 7001_ $$aTimmermans, Jean-Pierre,$$eauthor.
001436499 7001_ $$aAdriaensen, Dirk,$$eauthor.
001436499 77608 $$iPrint version:$$aBrouns, Inge.$$tPulmonary neuroepithelial body microenvironment.$$dCham, Switzerland : Springer, [2021]$$z9783030658168$$w(OCoLC)1255365221
001436499 830_0 $$aAdvances in anatomy, embryology, and cell biology ;$$vv. 233.$$x0301-5556
001436499 852__ $$bebk
001436499 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-65817-5$$zOnline Access$$91397441.1
001436499 909CO $$ooai:library.usi.edu:1436499$$pGLOBAL_SET
001436499 980__ $$aBIB
001436499 980__ $$aEBOOK
001436499 982__ $$aEbook
001436499 983__ $$aOnline
001436499 994__ $$a92$$bISE