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Title
The collagen superfamily and collagenopathies / Florence Ruggiero, editor.
ISBN
9783030675929 (electronic bk.)
3030675920 (electronic bk.)
3030675912
9783030675912
Publication Details
Cham : Springer, 2021.
Language
English
Description
1 online resource
Item Number
10.1007/978-3-030-67592-9 doi
Call Number
QP552.C6
Dewey Decimal Classification
572/.67
Summary
This book aims at providing insights into the collagen superfamily and the remarkable diversity of collagen function within the extracellular matrix. Additionally, the mechanisms underlying collagen-related diseases such as dystrophic epidermolysis bullosa, osteogenesis imperfecta, as well as collagen-related myopathies and neurological disorders are discussed. Collagens are the most abundant extracellular matrix proteins in organisms. Their primary function is to provide structural support and strength to cells and to maintain biomechanical integrity of tissues. However, collagens can no longer be considered just as structural proteins. They can act as extracellular modulators of signaling events and serve critical regulatory roles in various cell functions during embryonic development and adult homeostasis. Furthermore, collagens are associated with a broad spectrum of heritability-related diseases known as collagenopathies that affect a multitude of organs and tissues including sensorial organs. The book is a useful introduction to the field for junior scientists, interested in extracellular matrix research. It is also an interesting read for advanced scientists and clinicians working on collagens and collagenopathies, giving them a broader view of the field beyond their area of specialization.
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Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed May 21, 2021).
Series
Biology of extracellular matrix ; v. 8. 0887-3224
Chapter 1: Introduction to the collagen superfamily
Chapter 2: Collagen IV-related disease
Chapter 3: Articular collagens related diseases
Chapter 4: Collagens as new players of nervous system disease
Chapter 5: Collagens and EDS
Chapter 6: Collagens and dystrophic epidermolysis bullosa
Chapter 7: Collagen-related myopathies: pathogenic mechanisms and prospective therapies
Chapter 8: Procollagen trafficking and its implicaitons in Osteogenesis Imperfecta.