@article{1437022,
      recid = {1437022},
      author = {Limouris, Georgios S.,},
      title = {Liver intra-arterial PRRT with 111In-Octreotide : the  tumoricidal efficacy of 111In auger electron emission /},
      publisher = {Springer,},
      address = {Cham :},
      pages = {1 online resource},
      year = {2021},
      abstract = {This book describes in detail a clinical project that  reveals the tumoricidal efficacy of Auger and internal  conversion electrons, emitted from n.c.a. 111In and  implemented in oncology as a treating armamentarium for  peptide receptor radionuclide therapy (PRRT), targeting  small size (² d"20 mm) tumors and micro-metastases. The  keen interest in n.c.a. 111In began when it was observed  that its Auger electron emission could be highly  radiotoxic, due to its high LET when it decayed in the  vicinity of cellular DNA. The somatostatin analog  octreotide, labeled with  [111In-diethylenetriaminepentaacetic acid (DTPA0-D-Phe1)]  is an established diagnostic agent for the imaging of  somatostatin receptor-positive neuro- (or non-neuro)  endocrine tumors. It relies on receptor-mediated binding,  internalization and installation in the lysosomes in the  proximity of the nucleus; administered in large doses,  loco-regionally, via the feeding artery of solid tumors,  can be highly radiotoxic if they over-express somatostatin  receptors, mainly of the sst2 histotype. The book compares  the results between i.v. and i.a. implementation in more  than 80 patients after over 800 i.a. infusions in  neuroendocrine tumors, meningiomas, paragangliomas and  colorectal carcinomas in a single Institute (Aretaieion  University Hospital) and encourages the i.a. way, leading  to tumor melting while minimizing the toxicity to healthy  peritumoral liver tissue and critical organs (kidneys and  bone marrow). The volume is an invaluable tool for nuclear  medicine physicians, interventional radiologists and  oncologists dealing with radiopeptide therapies},
      url = {http://library.usi.edu/record/1437022},
      doi = {https://doi.org/10.1007/978-3-030-70773-6},
}