001437997 000__ 03696cam\a2200529\a\4500
001437997 001__ 1437997
001437997 003__ OCoLC
001437997 005__ 20230309004243.0
001437997 006__ m\\\\\o\\d\\\\\\\\
001437997 007__ cr\un\nnnunnun
001437997 008__ 210711s2021\\\\sz\\\\\\o\\\\\000\0\eng\d
001437997 019__ $$a1266288414$$a1266809404$$a1268573971$$a1284936726
001437997 020__ $$a9783030765712$$q(electronic bk.)
001437997 020__ $$a3030765717$$q(electronic bk.)
001437997 020__ $$z3030765709
001437997 020__ $$z9783030765705
001437997 0247_ $$a10.1007/978-3-030-76571-2$$2doi
001437997 035__ $$aSP(OCoLC)1259627322
001437997 040__ $$aYDX$$beng$$epn$$cYDX$$dGW5XE$$dEBLCP$$dOCLCO$$dOCLCF$$dVT2$$dDCT$$dUKAHL$$dDKU$$dOCLCO$$dOCLCQ$$dCOM$$dOCLCQ
001437997 049__ $$aISEA
001437997 050_4 $$aQP623
001437997 08204 $$a572.8/8$$223
001437997 24500 $$aRNA damage and repair /$$cIoly Kotta-Loizou, editor.
001437997 260__ $$aCham, Switzerland :$$bSpringer,$$c2021.
001437997 300__ $$a1 online resource
001437997 336__ $$atext$$btxt$$2rdacontent
001437997 337__ $$acomputer$$bc$$2rdamedia
001437997 338__ $$aonline resource$$bcr$$2rdacarrier
001437997 347__ $$atext file
001437997 347__ $$bPDF
001437997 5050_ $$aPart 1: RNA Damage and Repair in Prokaryotes -- Chapter 1: Endoribonucleases of the toxin-antitoxin systems induce abortive infection -- Chapter 2: The lifecycle of ribosomal RNA in bacteria -- Chapter 3: The Rtc RNA end healing and sealing system -- Part 2: RNA Damage and Repair in Eukaryotes -- Chapter 4: Oxidative and nitrative RNA modifications in plants -- Chapter 5: The role of ribonucleases in RNA damage, inactivation, and degradation -- Chapter 6: Cytoplasmic mRNA recapping: An unexpected form of RNA repair -- Part 3: RNA Damage in Human Diseases -- Chapter 7: Adenosine-to-Inosine RNA editing: a key RNA processing step rewriting transcriptome in normal physiology and diseases -- Chapter 8: RNA-mediated metabolic defects in microsatellite expansion diseases.
001437997 506__ $$aAccess limited to authorized users.
001437997 520__ $$aRibonucleic acid (RNA) is a macromolecule that plays a central role in cell physiology: RNA molecules act as intermediates between the deoxyribonucleic acid (DNA), where genetic information is stored, and proteins, which perform the necessary functions within the cell. Traditionally, the structural and functional properties of RNA are closely linked to gene expression. However, RNA-based enzymes, called ribozymes, are also involved in catalysis and small RNAs regulate key cellular processes, such as cell growth, division, differentiation, aging and death. RNA is a sensitive macromolecule that can be easily damaged by environmental conditions (ultraviolet radiation, oxidative stress) and biological factors (ribonucleases, ribotoxins, CRISPR-Cas systems). Therefore, cells have developed mechanisms to protect and/or repair RNA molecules. This book presents an overview of the biology of RNA damage, protection and repair in prokaryotes and eukaryotes. Individual chapters cover the expression regulation, enzymology and physiological role of such systems, and link them to important human diseases such as cancer and degenerative diseases.
001437997 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed July 16, 2021).
001437997 650_0 $$aRNA.
001437997 650_0 $$aDNA damage.
001437997 650_6 $$aARN.
001437997 650_6 $$aADN$$xLésions.
001437997 655_0 $$aElectronic books.
001437997 7001_ $$aKotta-Loizou, Ioly,$$eeditor.
001437997 77608 $$iPrint version:$$tRNA damage and repair.$$dCham, Switzerland : Springer, 2021$$z3030765709$$z9783030765705$$w(OCoLC)1247664846
001437997 852__ $$bebk
001437997 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-76571-2$$zOnline Access$$91397441.1
001437997 909CO $$ooai:library.usi.edu:1437997$$pGLOBAL_SET
001437997 980__ $$aBIB
001437997 980__ $$aEBOOK
001437997 982__ $$aEbook
001437997 983__ $$aOnline
001437997 994__ $$a92$$bISE