RNA damage and repair / Ioly Kotta-Loizou, editor.
Kotta-Loizou, Ioly, editor.
2021
QP623
Available Online

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Title
RNA damage and repair / Ioly Kotta-Loizou, editor.
ISBN
9783030765712 (electronic bk.)
3030765717 (electronic bk.)
3030765709
9783030765705
DOI
https://doi.org/10.1007/978-3-030-76571-2
Publication Details
Cham, Switzerland : Springer, 2021.
Language
English
Description
1 online resource
Item Number
10.1007/978-3-030-76571-2 doi
Call Number
QP623
Dewey Decimal Classification
572.8/8
Summary
Ribonucleic acid (RNA) is a macromolecule that plays a central role in cell physiology: RNA molecules act as intermediates between the deoxyribonucleic acid (DNA), where genetic information is stored, and proteins, which perform the necessary functions within the cell. Traditionally, the structural and functional properties of RNA are closely linked to gene expression. However, RNA-based enzymes, called ribozymes, are also involved in catalysis and small RNAs regulate key cellular processes, such as cell growth, division, differentiation, aging and death. RNA is a sensitive macromolecule that can be easily damaged by environmental conditions (ultraviolet radiation, oxidative stress) and biological factors (ribonucleases, ribotoxins, CRISPR-Cas systems). Therefore, cells have developed mechanisms to protect and/or repair RNA molecules. This book presents an overview of the biology of RNA damage, protection and repair in prokaryotes and eukaryotes. Individual chapters cover the expression regulation, enzymology and physiological role of such systems, and link them to important human diseases such as cancer and degenerative diseases.
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text file
PDF
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed July 16, 2021).
Added Author
Kotta-Loizou, Ioly, editor.
Available in Other Form
RNA damage and repair.
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Part 1: RNA Damage and Repair in Prokaryotes
Chapter 1: Endoribonucleases of the toxin-antitoxin systems induce abortive infection
Chapter 2: The lifecycle of ribosomal RNA in bacteria
Chapter 3: The Rtc RNA end healing and sealing system
Part 2: RNA Damage and Repair in Eukaryotes
Chapter 4: Oxidative and nitrative RNA modifications in plants
Chapter 5: The role of ribonucleases in RNA damage, inactivation, and degradation
Chapter 6: Cytoplasmic mRNA recapping: An unexpected form of RNA repair
Part 3: RNA Damage in Human Diseases
Chapter 7: Adenosine-to-Inosine RNA editing: a key RNA processing step rewriting transcriptome in normal physiology and diseases
Chapter 8: RNA-mediated metabolic defects in microsatellite expansion diseases.

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