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001438106 001__ 1438106
001438106 003__ OCoLC
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001438106 019__ $$a1261364913$$a1266811432$$a1268574054$$a1284944062
001438106 020__ $$a9789811602672$$q(electronic bk.)
001438106 020__ $$a9811602670$$q(electronic bk.)
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001438106 020__ $$z9811602662
001438106 0247_ $$a10.1007/978-981-16-0267-2$$2doi
001438106 035__ $$aSP(OCoLC)1260292064
001438106 040__ $$aYDX$$beng$$erda$$epn$$cYDX$$dEBLCP$$dGW5XE$$dOCLCO$$dDCT$$dUKAHL$$dDKU$$dOCLCF$$dOCLCQ$$dCOM$$dCASUM$$dOCLCQ
001438106 049__ $$aISEA
001438106 050_4 $$aRS431.A66$$bA58 2021
001438106 08204 $$a615.7/924$$223
001438106 24500 $$aAntiviral drug discovery and development /$$cXinyong Liu, Peng Zhan, Luis Menéndez-Arias, Vasanthanathan Poongavanam, editors.
001438106 264_1 $$aSingapore :$$bSpringer,$$c[2021]
001438106 264_4 $$c©2021
001438106 300__ $$a1 online resource :$$billustrations (some color)
001438106 336__ $$atext$$btxt$$2rdacontent
001438106 337__ $$acomputer$$bc$$2rdamedia
001438106 338__ $$aonline resource$$bcr$$2rdacarrier
001438106 347__ $$atext file
001438106 347__ $$bPDF
001438106 4901_ $$aAdvances in experimental medicine and biology ;$$vvolume 1322
001438106 5050_ $$a1 Antiviral Drugs Against Herpesviruses -- 2 An Update on Antiretroviral Therapy -- 3 Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and their Inhibition -- 4 LEDGINs, Inhibitors of the Interaction between HIV-1 Integrase and LEDGF/p75, are Potent Antivirals with a Potential to Cure HIV Infection -- 5 Moving Fast Towards Hepatitis B Virus Elimination -- 6 Discovery and Development of Antiviral Therapies for Chronic Hepatitis C Virus Infection -- 7 Phytoconstituents as Lead Compounds for Anti-dengue Drug Discovery -- 8 Anti-influenza Drug Discovery and Development: Targeting the Virus and its Host by all -- 9 Search, Identification and Design of Effective Antiviral Drugs against Pandemic Human Coronaviruses -- 10 Peptide Based Antiviral Drugs -- 11 Covalent Antiviral Agents -- 12 Safe-in-Man Broad Spectrum Antiviral Agents -- 13 Exploiting Ubiquitin ligases for Induced Target Degradation as an Antiviral Strategy.
001438106 506__ $$aAccess limited to authorized users.
001438106 520__ $$aThis book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting proteinprotein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
001438106 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed July 29, 2021).
001438106 650_0 $$aAntiviral agents$$xDesign.
001438106 655_0 $$aElectronic books.
001438106 7001_ $$aLiu, Xinyong,$$eeditor.
001438106 7001_ $$aZhan, Peng,$$eeditor.
001438106 7001_ $$aMenéndez-Arias, Luis,$$eeditor.
001438106 7001_ $$aPoongavanam, Vasanthanathan,$$eeditor.
001438106 77608 $$iPrint version:$$tAntiviral drug discovery and development.$$dSingapore : Springer, [2021]$$z9811602662$$z9789811602665$$w(OCoLC)1231958028
001438106 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 1322.
001438106 852__ $$bebk
001438106 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-16-0267-2$$zOnline Access$$91397441.1
001438106 909CO $$ooai:library.usi.edu:1438106$$pGLOBAL_SET
001438106 980__ $$aBIB
001438106 980__ $$aEBOOK
001438106 982__ $$aEbook
001438106 983__ $$aOnline
001438106 994__ $$a92$$bISE