@article{1438314,
      recid = {1438314},
      author = {Beretta, Giordano, and Berruti, Alfredo, and Bombardieri,  E. and Fazio, Nicola, and Goletti, Orlando,},
      title = {Neuroendocrine neoplasia management : new approaches for  diagnosis and treatment /},
      pages = {1 online resource (xiv, 331 pages) :},
      abstract = {"This book provides the most recent update on the  management of neuroendocrine neoplasia (NEN), a term  covering all tumors of various organs and/or with a  particular histology, including MEN (multiple endocrine  neoplasia) related tumors, MiNEN (mixed  neuroendocrine-non-neuroendocrine neoplasms), NEC  (neuroendocrine carcinoma) and Merkel's carcinoma. NENs are  heterogeneous in their biology, clinical presentation and  prognosis, showing a great variability in aggressiveness  and therapy response. As a result, their treatment is based  on a large spectrum of options. The standard therapies are  surgery in early disease, various loco-regional procedures  in certain conditions and mostly of a palliative nature in  metastatic disease. At present, thanks to our increased  understanding of molecular signaling pathways, several  pharmacological approaches can be used in patients with  advanced NENs. Somatostatin analogs display both anti-tumor  effects and symptom control. Novel peptide-radio-receptor  treatment (PRRT) is used in patients with well  differentiated tumors. The agents targeting angiogenesis  and/or PI3K/AKT/mTOR pathway, alone or in combination with  analogues, have provided encouraging results in advanced  disease. The first part of the book focuses on the history,  epidemiology and the most relevant scientific achievements,  covering the discoveries in genetic and molecular biology,  the endoscopic techniques with guided biopsy, and the  metabolic imaging with hybrid PET/CT and MRI/CT. It  particularly highlights the emerging strategies in therapy,  surgery and mini-invasive surgery as well as loco-regional  and systemic treatments, including targeted therapy and/or  biological therapies. The second part then explores the  management of NENs of various anatomical origins and/or  with peculiar biology. It describes the range of the  current options and the most relevant results from the  clinical trials. This informative book provides valuable  insights for all those interested in the management of  neuroendocrine neoplasia."--Publisher's description},
      url = {http://library.usi.edu/record/1438314},
      doi = {https://doi.org/10.1007/978-3-030-72830-4},
}