TY  - GEN
AB  - This book provides a useful resource for graduate-level cancer cell biology courses. Since the first report, in 1994, of "anoikis" the apoptosis that occurs when cells lack appropriate contact with the extracellular matrixover 2,100 papers have been published on this subject. This book is the first comprehensive, in-depth and up-to-date compendium on anoikis. Chapters are authored by some of the leading researchers in the field. This book provides both mechanistic and translational information regarding anoikis, in a convenient format. Mechanistically, the following topics will be addressed in detail: The role of MAP kinase signaling The role of Shc proteins as cellular anchorage sensors The role of cellular metabolism, and fatty acid metabolism in particular, and how they are affected by oncogenic transformation How epithelial cell extrusion the prelude to anoikisis regulated in normal and cancer cells The convergence of TGF-b and androgen receptor signaling in the regulation of anoikis This book also discusses the specialized functions and dysregulation of anoikis in the following cancer settings: Colon cancer Melanoma Cervical cancer The book serves to update i nvestigators actively working on problems in the anoikis field, in either experimental or translational settings. For investigators encountering novel biological phenomena that might relate to anoikis, it serve as an entry point to the literature that does not require an extensive background in cell adhesion signaling or apoptosis mechanisms
AU  - Frisch, Steven Miles,
CN  - QH671
DO  - 10.1007/978-3-030-73856-3
DO  - doi
ID  - 1438524
KW  - Apoptosis.
KW  - Extracellular matrix.
KW  - Apoptose.
KW  - Substance fondamentale (Histologie)
LK  - https://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-73856-3
N2  - This book provides a useful resource for graduate-level cancer cell biology courses. Since the first report, in 1994, of "anoikis" the apoptosis that occurs when cells lack appropriate contact with the extracellular matrixover 2,100 papers have been published on this subject. This book is the first comprehensive, in-depth and up-to-date compendium on anoikis. Chapters are authored by some of the leading researchers in the field. This book provides both mechanistic and translational information regarding anoikis, in a convenient format. Mechanistically, the following topics will be addressed in detail: The role of MAP kinase signaling The role of Shc proteins as cellular anchorage sensors The role of cellular metabolism, and fatty acid metabolism in particular, and how they are affected by oncogenic transformation How epithelial cell extrusion the prelude to anoikisis regulated in normal and cancer cells The convergence of TGF-b and androgen receptor signaling in the regulation of anoikis This book also discusses the specialized functions and dysregulation of anoikis in the following cancer settings: Colon cancer Melanoma Cervical cancer The book serves to update i nvestigators actively working on problems in the anoikis field, in either experimental or translational settings. For investigators encountering novel biological phenomena that might relate to anoikis, it serve as an entry point to the literature that does not require an extensive background in cell adhesion signaling or apoptosis mechanisms
SN  - 9783030738563
SN  - 3030738566
T1  - Anoikis :how the extracellular matrix regulates life-or-death decisions /
TI  - Anoikis :how the extracellular matrix regulates life-or-death decisions /
UR  - https://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-73856-3
ER  -