Intro
Introduction
Contents
1 Metabolic Contributions to Anoikis-Resistance in Metastatic Dissemination
Abstract
1 Introduction
2 Bioenergetics
2.1 Glycolysis
2.2 Glutaminolysis
2.3 Autophagy
3 Redox Control
3.1 Restricted Glucose Oxidation
3.2 Antioxidant Defenses
3.3 ROS-Mediated Anti-apoptotic Signaling
4 Conclusion
References
2 Metabolic Reprogramming and the Control of Anoikis Resistance in Cancer
Abstract
1 Metabolic Signal Integrators
1.1 The PI3K/Akt-mTOR Pathway
1.2 The Ras-MAPK Pathway

1.3 Myc and HIF-1 Transcription Factors
1.4 AMPK Pathway
2 ECM Attachment-Dependent Signaling Pathways that Regulate Cell Metabolism
3 An Overview of Model Systems Used to Study Anoikis
4 Metabolic Adaptations of Detached Cancer Cells-Roles in Anoikis-Resistance and Metastasis
4.1 Glucose Metabolism
4.2 Amino Acid Metabolism
4.3 Redox Homeostasis
4.3.1 Antioxidant Enzymes in Anoikis-Resistance
4.3.2 Mechanisms to Reduce ROS Generation
4.3.3 Synthesis of Reducing Equivalents
4.3.4 Mitochondrial ROS and Anoikis
4.4 Lipid Metabolism

5 HIF-1 and Anoikis-Resistance
6 Autophagy and Its Role in the Regulation of Metabolic Stress and Anoikis
7 Metabolic Switch in Detached Cells-The Tug of War Between AMPK and Akt
Acknowledgement
References
3 The Intersection of Anoikis Resistance and Fatty Acid Metabolism in Cancer
Abstract
1 Introduction
2 Metabolic Plasticity
3 Fatty Acid Oxidation
4 Stemness and Fatty Acid Oxidation
5 FAO in Ovarian Cancer
6 FAO-Mediated Signaling and Anoikis Resistance
7 Receptor Tyrosine Kinase Contribution to Metabolic Reprogramming
8 Conclusions
References

4 Shc and the Control of Small GTPase Dynamics in Cellular Anchorage
Abstract
1 Cellular Anchorage and the Importance of Shape Change
2 Regulation of Shape Change by Rho GTPases
3 Rho GTPases and Abnormal Matrix Signaling in Cancer
4 p52Shc and the Control of Mechanical Signals
5 Distinct Functional Roles for p66Shc
6 Control of RhoA and Anoikis by p66Shc
7 p66Shc and Metastatic Behavior
8 Epigenetic Control of SHC1 and Implications for Lineage Shifting
9 Summary
References
5 Anoikis and the Human Gut Epithelium in Health and Disease
Abstract

1 Anoikis: Back to (General) Basics
1.1 A Brief Word on Apoptosis
1.2 Cell-ECM and Cell-Cell Interactions
1.2.1 Integrins
1.2.2 E-cadherin
1.3 Enter Anoikis
1.3.1 Anoikis and Integrins
1.3.2 Anoikis and E-cadherin
2 Anoikis and the Human Gut Epithelium in Health
2.1 Anoikis and the Renewal of the Human Gut Epithelium
2.1.1 A Few Words on the Regulation of hIEC Survival
2.1.2 hIEC Anoikis: Sensitivity Versus State of Differentiation
2.2 hIEC Anoikis and Integrins
2.3 hIEC Anoikis and E-cadherin
3 Anoikis and the Human Gut Epithelium in Disease