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001438551 001__ 1438551
001438551 003__ OCoLC
001438551 005__ 20230309004311.0
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001438551 020__ $$a9783030716127$$q(electronic bk.)
001438551 020__ $$a3030716120$$q(electronic bk.)
001438551 020__ $$z3030716112
001438551 020__ $$z9783030716110
001438551 0247_ $$a10.1007/978-3-030-71612-7$$2doi
001438551 035__ $$aSP(OCoLC)1262368343
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001438551 049__ $$aISEA
001438551 050_4 $$aQH450.2$$b.E65 2021
001438551 08204 $$a572.8/845$$223
001438551 24500 $$aEpitranscriptomics /$$cStefan Jurga, Jan Barciszewski, editors.
001438551 264_1 $$aCham, Switzerland :$$bSpringer,$$c2021.
001438551 300__ $$a1 online resource
001438551 336__ $$atext$$btxt$$2rdacontent
001438551 337__ $$acomputer$$bc$$2rdamedia
001438551 338__ $$aonline resource$$bcr$$2rdacarrier
001438551 4901_ $$aRNA Technologies,$$x2197-9731 ;$$vv. 12
001438551 5050_ $$aEpitranscriptomic Modifications and How to Find them -- Epitranscriptomic Signature in Neural Development and Disease -- The Emerging Neuroepitranscriptome -- Epitranscriptomics and Diseases -- Epitranscriptomic Marks and Systems Involved in Gene Regulation, Development and Disease -- Experimental Approaches and Computational Workflows for Systematic Mapping and Functional Interpretation of RNA Modifications -- RNA Modifications: The Mediator Between Cellular Stresses and Biological Effects -- Computational Prediction and Experimental Validation of Specific Modified RNA Sites -- Regulation of RNA Stability Utilizing RNA Modification -- Dynamic RNA Modification Upon Extracellular Stimulus -- RNA Methylation in Cancer -- Regulation of RNA Methylation yy TET Enzymes -- RNA N6-Methyladenosine and G-Quadruplex Structures in Bacteria -- RNA N6-Methyladenosine Chemical Modification as a Therapeutic Target -- Cap-Adjacent m6Am and its Effects On mRNA -- N6-Methyladenosine in The Heart -- The m6a RNA Methylation Regulates Oncogenic Signaling Pathways Driving Cell Transformation and Carcinogenesis -- Psivar: A Database of Functional Variants Involved in Pseudouridylation (?) with Implications for Disease Pathogenesis -- C-to-U RNA Editing by Mammalian APOBEC Enzymes -- The Powerful Mechanism of RNA Editing and its Therapeutic Potentials -- Noncanonical Caps in RNA -- Mass Spectrometry-Based Methods for Characterization of Hypomodifications in tRNA -- Dynamic mRNA Modifications in Plants -- The Mammalian Mitochondrial Epitranscriptome -- Epitranscriptomics Modifications of Micrornas: Classes, Detection, Impact on their Functionality and Next Frontiers -- "Look Before You Leap" when Editing the Introns, or the Secrets Behind the Intronic Post-Transcriptional Modification -- Functional Links Between the Internal N6-Methyl Adenosine Modifications in mRNAs and Human Diseases -- RNA Modifications in Neurodevelopment and Neurodegenerations -- Conventional and Advanced Techniques for Methyl-6-Adenosine Modification Mapping in Transcripts -- Mechanisms and Therapeutic Applications of RNA-Guided RNA Pseudouridylation -- Epitranscriptomic Modifications in lnRNA and miRNA in Cancer and Other Diseases -- RNA m6A and Adipogenesis.
001438551 506__ $$aAccess limited to authorized users.
001438551 520__ $$aThis book reviews a novel and exciting ld of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism's cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person's biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.
001438551 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed August 11, 2021).
001438551 650_0 $$aGenetic transcription.
001438551 650_0 $$aRNA.
001438551 650_6 $$aTranscription génétique.
001438551 650_6 $$aARN.
001438551 655_0 $$aElectronic books.
001438551 7001_ $$aJurga, Stefan,$$eeditor.
001438551 7001_ $$aBarciszewski, Jan,$$eeditor.
001438551 77608 $$iPrint version:$$z3030716112$$z9783030716110$$w(OCoLC)1237634398
001438551 830_0 $$aRNA technologies ;$$vv. 12.$$x2197-9731
001438551 852__ $$bebk
001438551 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-71612-7$$zOnline Access$$91397441.1
001438551 909CO $$ooai:library.usi.edu:1438551$$pGLOBAL_SET
001438551 980__ $$aBIB
001438551 980__ $$aEBOOK
001438551 982__ $$aEbook
001438551 983__ $$aOnline
001438551 994__ $$a92$$bISE