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001438859 001__ 1438859
001438859 003__ OCoLC
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001438859 019__ $$a1263871876
001438859 020__ $$a9783030620264$$q(electronic bk.)
001438859 020__ $$a3030620263$$q(electronic bk.)
001438859 020__ $$z3030620255
001438859 020__ $$z9783030620257
001438859 0247_ $$a10.1007/978-3-030-62026-4$$2doi
001438859 035__ $$aSP(OCoLC)1263864847
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001438859 049__ $$aISEA
001438859 050_4 $$aQH671
001438859 08204 $$a571.9/36$$223
001438859 24500 $$aFerroptosis:$$bmechanism and diseases /$$cAndrés F. Florez, Hamed Alborzinia, editors.
001438859 260__ $$aCham, Switzerland :$$bSpringer,$$c2021.
001438859 300__ $$a1 online resource
001438859 336__ $$atext$$btxt$$2rdacontent
001438859 337__ $$acomputer$$bc$$2rdamedia
001438859 338__ $$aonline resource$$bcr$$2rdacarrier
001438859 4901_ $$aAdvances in Experimental Medicine and Biology ;$$vv. 1301
001438859 500__ $$aIncludes index.
001438859 5050_ $$aIntro -- Foreword -- Contents -- About the Editors -- 1: Ferroptosis: Concepts and Definitions -- References -- 2: Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT Inhibitors -- 2.1 Pancreatic Cancer Therapeutic Challenges -- 2.2 Ferroptosis and PDAC -- 2.2.1 xCT-Based Ferroptosis Inducers as Systemic Therapeutics for PDAC -- 2.2.2 xCT-Based Early Detection of Metastasized PDAC -- 2.3 Metabolic Status Dictates Sensitivity Toward Ferroptosis -- 2.4 Promoting Ferroptosis and Antigenicity in PDAC
001438859 5058_ $$a2.5 How Stromal Compartment Influences Sensitivity to Ferroptosis -- 2.6 Concluding Remarks -- References -- 3: Iron Homeostasis and Metabolism: Two Sides of a Coin -- 3.1 Iron in Physiology and Disease -- 3.1.1 Iron: Origin, Chemical Properties and Evolution -- 3.1.2 Insights into the Redox Chemistry of Iron -- 3.1.3 Strategies for Iron Assimilation and Transport -- 3.2 Concluding Remarks -- References -- 4: The Role of NCOA4-Mediated Ferritinophagy in Ferroptosis -- 4.1 Introduction -- 4.2 NCOA4-Mediated Ferritinophagy -- 4.3 NCOA4-Mediated Ferritinophagy and Ferroptosis
001438859 5058_ $$a4.4 Ferritinophagy and Ferroptosis in Cancer -- 4.5 Ferritinophagy and Ferroptosis in Neurodegeneration -- 4.5.1 Neuroferritinopathy -- 4.5.2 Alzheimer's Disease -- 4.5.3 Parkinson's Disease -- 4.5.4 Huntington's Disease -- 4.5.5 Amyotrophic Lateral Sclerosis -- 4.5.6 Brain Injury -- 4.6 Conclusions and Future Directions -- References -- 5: Emerging Role for Ferroptosis in Infectious Diseases -- 5.1 Introduction -- 5.2 Necrosis in Infectious Diseases -- 5.2.1 Pyroptosis and Necroptosis in Infectious Diseases -- 5.3 Ferroptosis in Infectious Diseases
001438859 5058_ $$a5.3.1 Pathogen-Induced Ferroptotic Cell Death -- 5.3.1.1 Bacterial Infections -- Salmonella Typhimurium Infection -- Mycobacterium tuberculosis Infection -- Pseudomonas aeruginosa Infection -- Polymicrobial Sepsis -- 5.3.1.2 Viral Infection -- 5.3.1.3 Parasitic Infection -- 5.4 Concluding Remarks -- References -- 6: Small Molecule Regulators of Ferroptosis -- 6.1 Introduction -- 6.2 Activators of Ferroptosis -- 6.2.1 Targeting GPX4 Activity and Lipid Production -- 6.2.1.1 Deficiency of GPX4 Production (Scheme 6.1 -- Fig. 6.2) -- 6.2.1.2 Boost of Lipid Production (Scheme 6.1
001438859 5058_ $$aFig. 6.3) -- 6.2.2 GSH Depletion and Nuclear Factor (Erythroid-Derived 2)-like 2 (NrF2) Inhibition -- 6.2.2.1 System Xc- Inhibition (Scheme 6.1 -- Fig. 6.4) -- 6.2.2.2 Alteration of GSH Metabolism (Scheme 6.1 -- Fig. 6.5) -- 6.2.2.3 NrF2 Inhibition (Scheme 6.1 -- Fig. 6.6) -- 6.2.3 Iron and ROS Production -- 6.2.3.1 Labile iron Pool Enrichment (Scheme 6.2 -- Fig. 6.7) -- 6.2.3.2 Inducing ROS (Scheme 6.2 -- Fig. 6.9) -- 6.2.3.3 A Small molecule Inducer of Membrane Leakage (Scheme 6.2 -- Fig. 6.10) -- 6.3 Inhibitors of Ferroptosis
001438859 506__ $$aAccess limited to authorized users.
001438859 520__ $$aThis book focuses on the emerging role of ferroptosis in human diseases. It gives a detailed perspective on how to induce or suppress ferroptosis to treat challenging conditions such as infectious diseases, including COVID-19, tuberculosis, parasitic diseases and cancer. The book serves as a practical guide by providing a valuable collection of all currently known activators or inhibitors of ferroptosis. It will enable readers to choose molecules for experimental design for in vitro and in vivo studies of ferroptosis. Furthermore, this volume highlights the aspects of iron metabolism and its connection to ferritinophagy, a ferritin selective autophagy, with profound implications in neurodegenerative diseases such as Alzheimer, Parkinson, Huntington and ALS. Lastly, it describes necroptosis, another important form of cell death, along with its connections to human disorders and potential crosstalk with ferroptosis. While covering basic concepts, the book delves into mechanisms and modulation of ferroptosis for treating a wide variety of human diseases thus offering a valuable and informative resource for both, scientists and clinical researchers.
001438859 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed August 23, 2021).
001438859 650_0 $$aCell death.
001438859 650_0 $$aIron$$xPhysiological effect.
001438859 650_6 $$aCellules$$xMort.
001438859 650_6 $$aFer$$xEffets physiologiques.
001438859 655_0 $$aElectronic books.
001438859 7001_ $$aFlorez, Andrés F.
001438859 7001_ $$aAlborzinia, Hamed.
001438859 77608 $$iPrint version:$$z3030620255$$z9783030620257$$w(OCoLC)1196840053
001438859 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 1301.
001438859 852__ $$bebk
001438859 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-62026-4$$zOnline Access$$91397441.1
001438859 909CO $$ooai:library.usi.edu:1438859$$pGLOBAL_SET
001438859 980__ $$aBIB
001438859 980__ $$aEBOOK
001438859 982__ $$aEbook
001438859 983__ $$aOnline
001438859 994__ $$a92$$bISE