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Recent advances in NGF and related molecules : the continuum of the NGF "Saga" / Laura Calzà, Luigi Aloe, Luciana Giardino, editors.

Calzà, Laura, editor.; Aloe, Luigi, editor.; Giardino, Luciana, editor.
2021
QP552.N36
Available Online
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Title
Recent advances in NGF and related molecules : the continuum of the NGF "Saga" / Laura Calzà, Luigi Aloe, Luciana Giardino, editors.
ISBN
9783030740467 (electronic bk.)
3030740463 (electronic bk.)
9783030740450
3030740455
DOI
https://doi.org/10.1007/978-3-030-74046-7
Published
Cham, Switzerland : Springer, 2021.
Language
English
Description
1 online resource (xi, 307 pages) : illustrations (some color).
Item Number
10.1007/978-3-030-74046-7 doi
Call Number
QP552.N36
Dewey Decimal Classification
612.81
Summary
More than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs). This book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted increasing interest in the neuroscience community because of their diverse effects in the normal and diseased brain. In the first part of the book, the authors provide the necessary background for the following chapters and discuss the basic mechanisms and pathways of NGF signal transduction. In the following sections, they then examine the regenerative activity and neuroprotective capacity of NGF during development and in normal and diseased tissues in adulthood and discuss the role of NGF in Alzheimer's disease and nociception. In addition, the role of NGF in processing sensory information and its influence on behavior is further discussed. The book concludes with an overview of the diagnostic and therapeutic potential of NTF in psychiatric disorders and obesity management, as well as a highlight of NGF research in veterinary medicine. Many of the authors of this volume participated in the Second International Rita Levi-Montalcini Meeting, held in Bologna, Italy, in 2019. The book covers a wide range of important topics in past and current NTF research and will appeal to basic researchers and clinicians alike.
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Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed August 31, 2021).
Added Author
Calzà, Laura, editor.
Aloe, Luigi, editor.
Giardino, Luciana, editor.
Series
Advances in experimental medicine and biology ; v. 1331.
Available in Other Form
Recent advances in NGF and related molecules.
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Part I. Basic Science
Nerve Growth Factor, The First Molecule of the Neurotrophin Family
The First and Last Time I Met Rita Levi-Montalcini: From the Insect Neurotrophic Factor to the Nerve Growth Factor Clinical Application
NGF Signalling in Endosomes
The NGF Metabolic Pathway: New Opportunities for Biomarker Research and Drug Target Discovery
Part II. Development and Regeneration
NGF and Endogenous Regeneration: From Embryology Toward Therapies
The Versatile Roles of Nerve Growth Factor in Neuronal Attraction, Odontoblast Differentiation and Mineral Deposition in Human Teeth
An Overview of Adult Neurogenesis
Intervention of Brain-Derived Neurotrophic Factor and Other Neurotrophins in Adult Neurogenesis
Part III. Alzheimer and Central Nervous System
Rita Levi-Montalcini, NGF Metabolism in Health and in the Alzheimer's Pathology
NGF and Amyloid Precursor Protein in Alzheimer's Disease: From Molecular Players to Neuronal Circuits
A Review of Techniques for Biodelivery of Nerve Growth Factor (NGF) to the Brain in Relation to Alzheimers Disease
NGF Released from Blood Cells or Collagen Hydrogels as a Therapeutic Target in Alzheimers Disease?
Part IV. Complex Behaviors
When Nerve Growth Factor Met Behavior
Crosstalk of BDNF and GDNF in Spinal Substantia Gelatinosa (Lamina II): Focus on Circuitry
PART V. Clinical Medicine
BDNF Gene as a Precision Skill of Obesity Management
The Science of Love: State of the Art
NGF and Retinitis Pigmentosa: Structural and Molecular Studies
NGF in Inflammatory and Neurodegenerative Diseases of the Eye: New Findings Supporting Neuroprotection and Proper Tissue Remodeling in Vitreoretinal Disorders
Part VI. Veterinary Medicine
Nerve Growth Factor (NGF) and Animal Reproduction
Neurotrophins in the Brain of Teleost Fish: The State of the Art.

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