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Table of Contents
Intro
Preface
Contents
Conventional and Emerging Markers in Stem Cell Isolation and Characterization
1 Introduction
2 Conventional Markers
2.1 Neural Stem Cell (NSC) Markers
2.2 Epidermal Stem Cell Markers
2.3 Mesenchymal Stem Cell (MSC) Markers
3 Emerging Markers
3.1 Neural Stem Cell (NSC) Markers
3.2 Epidermal Markers
3.3 Cardiac Stem Cell Markers
3.4 Osteoprogenitor Markers
3.5 Mesenchymal Stem Cell (MSC) Markers
3.6 Intestinal Stem Cell Markers
4 Conclusion
References
Therapeutic Potential of Adipose Stem Cells
1 Introduction
2 ASCs in Regenerative Medicine
2.1 ASCs as Therapy for Cardiac Disease
2.2 ASCs and Biomaterials
2.2.1 ASC and Biomaterials for Angiogenesis
3 ASCs as Immunomodulators
3.1 ASCs as Therapy for Autoimmune Diseases
3.1.1 Multiple Sclerosis
3.1.2 Rheumatoid Arthritis
3.1.3 Type 1 Diabetes Mellitus
3.2 ASCs in Neurodegenerative Diseases
3.2.1 Alzheimerś Disease
3.2.2 Parkinsonś Disease
3.2.3 Amyotrophic Lateral Sclerosis
4 Clinical Applications of ASCs
4.1 Clinical Trials
5 Future Directions
References
Decellularized Extracellular Matrix as a Potent Natural Biomaterial for Regenerative Medicine
1 Introduction
2 Natural Extracellular Matrix (ECM), a Naïve Version of ECM Versus Decellularized ECM (dECM)
3 Versatility of Decellularization Protocols
3.1 The Efficiency of Physical Methods for Decellularization
3.2 The Efficiency of Chemical Methods for Decellularization
3.3 Combined Chemical and Physical Methods for Decellularization
3.4 Combination of Chemical and Enzymatic Methods for Decellularization
3.5 The Combination of Physical, Chemical, and Enzymatic Methods for Decellularization
4 Challenges Faced by Emerging Decellularization Technique
5 Potential Opportunities and Possibilities
5.1 Extracellular Matrix (ECM)-Based Bioink
5.2 Particulate Form of the Extracellular Matrix (ECM)
5.3 Mimicking the Vascular System
6 Conclusion and Outlooks
References
Stem Cell Based Exosomes: Are They Effective in Disease or Health?
1 Introduction
2 Gene Delivery Systems
3 Stem Cells and Their Exosomes
3.1 Exosomes or Stem Cells?
4 Synthetic Exosome-Mimics
5 Banking of Exosomes
5.1 Exosome Isolation and Characterization Methods
5.2 Exosomes Storage Conditions
6 Manufacturing Exosomes
7 Conclusion
References
Interests of Exosomes in Bone and Periodontal Regeneration: A Systematic Review
1 Introduction
2 Materials and Methods
2.1 Focused Question
2.2 Screening and Selection Criteria
2.3 Eligibility Criteria
2.4 Outcomes
3 Results
3.1 Study Selection
3.2 Studies Characteristics
3.3 Induction of the Periodontal or Bony Defect
3.4 Exosomes Sources
3.5 Mode of Exosomes Administration and Dose
3.6 Timing and Administration of Exosomes.
Preface
Contents
Conventional and Emerging Markers in Stem Cell Isolation and Characterization
1 Introduction
2 Conventional Markers
2.1 Neural Stem Cell (NSC) Markers
2.2 Epidermal Stem Cell Markers
2.3 Mesenchymal Stem Cell (MSC) Markers
3 Emerging Markers
3.1 Neural Stem Cell (NSC) Markers
3.2 Epidermal Markers
3.3 Cardiac Stem Cell Markers
3.4 Osteoprogenitor Markers
3.5 Mesenchymal Stem Cell (MSC) Markers
3.6 Intestinal Stem Cell Markers
4 Conclusion
References
Therapeutic Potential of Adipose Stem Cells
1 Introduction
2 ASCs in Regenerative Medicine
2.1 ASCs as Therapy for Cardiac Disease
2.2 ASCs and Biomaterials
2.2.1 ASC and Biomaterials for Angiogenesis
3 ASCs as Immunomodulators
3.1 ASCs as Therapy for Autoimmune Diseases
3.1.1 Multiple Sclerosis
3.1.2 Rheumatoid Arthritis
3.1.3 Type 1 Diabetes Mellitus
3.2 ASCs in Neurodegenerative Diseases
3.2.1 Alzheimerś Disease
3.2.2 Parkinsonś Disease
3.2.3 Amyotrophic Lateral Sclerosis
4 Clinical Applications of ASCs
4.1 Clinical Trials
5 Future Directions
References
Decellularized Extracellular Matrix as a Potent Natural Biomaterial for Regenerative Medicine
1 Introduction
2 Natural Extracellular Matrix (ECM), a Naïve Version of ECM Versus Decellularized ECM (dECM)
3 Versatility of Decellularization Protocols
3.1 The Efficiency of Physical Methods for Decellularization
3.2 The Efficiency of Chemical Methods for Decellularization
3.3 Combined Chemical and Physical Methods for Decellularization
3.4 Combination of Chemical and Enzymatic Methods for Decellularization
3.5 The Combination of Physical, Chemical, and Enzymatic Methods for Decellularization
4 Challenges Faced by Emerging Decellularization Technique
5 Potential Opportunities and Possibilities
5.1 Extracellular Matrix (ECM)-Based Bioink
5.2 Particulate Form of the Extracellular Matrix (ECM)
5.3 Mimicking the Vascular System
6 Conclusion and Outlooks
References
Stem Cell Based Exosomes: Are They Effective in Disease or Health?
1 Introduction
2 Gene Delivery Systems
3 Stem Cells and Their Exosomes
3.1 Exosomes or Stem Cells?
4 Synthetic Exosome-Mimics
5 Banking of Exosomes
5.1 Exosome Isolation and Characterization Methods
5.2 Exosomes Storage Conditions
6 Manufacturing Exosomes
7 Conclusion
References
Interests of Exosomes in Bone and Periodontal Regeneration: A Systematic Review
1 Introduction
2 Materials and Methods
2.1 Focused Question
2.2 Screening and Selection Criteria
2.3 Eligibility Criteria
2.4 Outcomes
3 Results
3.1 Study Selection
3.2 Studies Characteristics
3.3 Induction of the Periodontal or Bony Defect
3.4 Exosomes Sources
3.5 Mode of Exosomes Administration and Dose
3.6 Timing and Administration of Exosomes.