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001439536 001__ 1439536
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001439536 019__ $$a1267766931$$a1268573569$$a1284934063
001439536 020__ $$a9783030744489$$q(electronic bk.)
001439536 020__ $$a3030744485$$q(electronic bk.)
001439536 020__ $$z3030744469
001439536 020__ $$z9783030744465
001439536 0247_ $$a10.1007/978-3-030-74448-9$$2doi
001439536 035__ $$aSP(OCoLC)1267585879
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001439536 049__ $$aISEA
001439536 050_4 $$aRC281.C4
001439536 08204 $$a618.92/994$$223
001439536 24504 $$aThe hereditary basis of childhood cancer /$$cDavid Malkin, editor.
001439536 260__ $$aCham, Switzerland :$$bSpringer,$$c2021.
001439536 300__ $$a1 online resource
001439536 336__ $$atext$$btxt$$2rdacontent
001439536 337__ $$acomputer$$bc$$2rdamedia
001439536 338__ $$aonline resource$$bcr$$2rdacarrier
001439536 347__ $$atext file
001439536 347__ $$bPDF
001439536 500__ $$aIncludes index.
001439536 5050_ $$a1: Li-Fraumeni Syndrome -- 2: Pediatric Central Nervous System Cancer Predisposition -- 3: Rhabdoid Tumors -- 4: Neurofibromatosis -- 5: Pheochromocytoma and Paraganglioma syndromes -- 6: Wilms tumor -- 7: Hereditary Overgrowth Syndromes -- 8: Multiple Endocrine Neoplasias and Associated Non-Endocrine Conditions -- 9: DICER1 Syndrome -- 10: Cancer-prone Inherited Bone Marrow Failure, Myelodysplastic and Acute Myeloid Leukemia Syndromes -- 11: Inherited Risk for Childhood Leukemia -- 12: Inherited pediatric cancer in low and intermediate resource countries -- 13: Frontline Ethico-legal Issues in Childhood Cancer Genetics Research -- 14: Genetic counseling and testing -- 15: Psychosocial aspects of childhood cancer genetics -- 16: Recognition of cancer predisposition syndromes.
001439536 506__ $$aAccess limited to authorized users.
001439536 520__ $$aThis volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the disease-related chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical manifestations, to relate the relationship of the molecular oncologic pathways with relevant developmental or non-human species biology in order to better understand the complexity of these systems. The resulting clinical implications of understanding this biology are elaborated on. Chapters 13-16 discuss the broader psychosocial, ethical and genetic counseling issues that arise and that are so critical to translating the knowledge gained from advances in molecular genetics into the clinic. Chapter 12 in particular provides a unique perspective of the application of this knowledge in less-developed nations where modern technologies may not be readily available, but where the clinical manifestations of these disorders are prevalent.
001439536 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed September 24, 2021).
001439536 650_0 $$aCancer in children$$xGenetic aspects.
001439536 650_0 $$aCancer in children$$xMolecular aspects.
001439536 650_6 $$aCancer chez l'enfant$$xAspect génétique.
001439536 650_6 $$aCancer chez l'enfant$$xAspect moléculaire.
001439536 655_0 $$aElectronic books.
001439536 7001_ $$aMalkin, David$$c(Oncologist),$$eeditor.
001439536 77608 $$iPrint version:$$tHereditary basis of childhood cancer.$$dCham, Switzerland : Springer, 2021$$z3030744469$$z9783030744465$$w(OCoLC)1242465194
001439536 852__ $$bebk
001439536 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-74448-9$$zOnline Access$$91397441.1
001439536 909CO $$ooai:library.usi.edu:1439536$$pGLOBAL_SET
001439536 980__ $$aBIB
001439536 980__ $$aEBOOK
001439536 982__ $$aEbook
001439536 983__ $$aOnline
001439536 994__ $$a92$$bISE