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001439566 001__ 1439566
001439566 003__ OCoLC
001439566 005__ 20230309004435.0
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001439566 019__ $$a1268573622$$a1284937788
001439566 020__ $$a9783030701154$$q(electronic bk.)
001439566 020__ $$a3030701158$$q(electronic bk.)
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001439566 020__ $$z9783030701147
001439566 0247_ $$a10.1007/978-3-030-70115-4$$2doi
001439566 035__ $$aSP(OCoLC)1267753240
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001439566 049__ $$aISEA
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001439566 08204 $$a572/.567$$223
001439566 24504 $$aThe role of glycosylation in health and disease /$$cedited by Gordan Lauc, Irena Trbojević-Akmačić.
001439566 260__ $$aCham, Switzerland :$$bSpringer,$$c2021.
001439566 300__ $$a1 online resource
001439566 336__ $$atext$$btxt$$2rdacontent
001439566 337__ $$acomputer$$bc$$2rdamedia
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001439566 347__ $$atext file
001439566 347__ $$bPDF
001439566 4901_ $$aAdvances in experimental medicine and biology,$$x2214-8019 ;$$vv. 1325
001439566 500__ $$aIncludes index.
001439566 5050_ $$aN-glycosylation -- Mucin type O-GalNAc glycosylation in health and disease -- Glycosphingolipids -- Glycosaminoglycans -- Other types of glycosylation -- Extracellular vesicles and glycosylation -- Quantitative genetics of human protein N-glycosylation -- Epigenetic regulation of glycosylation -- Glycosaminoglycans in neurodegenerative diseases -- Glycosylation in autoimmune diseases -- The role of glycosylation in infectious diseases -- The importance of glycosylation in COVID-19 infection -- The role of glycosylation in inflammatory diseases -- Protein glycosylation in diabetes -- Glycosylation and cardiovascular diseases -- Glycosylation profiling as a biomarker of suboptimal health for chronic disease stratification -- Glycosylation and aging.
001439566 506__ $$aAccess limited to authorized users.
001439566 520__ $$aGlycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycanns' functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.
001439566 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed September 20, 2021).
001439566 650_0 $$aGlycosylation.
001439566 650_6 $$aGlycosylation.
001439566 655_0 $$aElectronic books.
001439566 7001_ $$aLauc, Gordan,$$d1970-$$eeditor$$1https://orcid.org/0000-0003-1840-9560
001439566 7001_ $$aTrbojević-Akmačić, Irena,$$eeditor.$$0(orcid)0000-0003-0106-0155$$1https://orcid.org/0000-0003-0106-0155
001439566 77608 $$iPrint version:$$tRole of glycosylation in health and disease.$$dCham, Switzerland : Springer, 2021$$z303070114X$$z9783030701147$$w(OCoLC)1233166854
001439566 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 1325.$$x2214-8019
001439566 852__ $$bebk
001439566 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-70115-4$$zOnline Access$$91397441.1
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