Cardiomyocytes in health and disease / Chandrasekharan C. Kartha.
Kartha, C. Chandrasekharan, author.
2021
QP114.C44 K37 2021
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Title
Cardiomyocytes in health and disease / Chandrasekharan C. Kartha.
Author
Kartha, C. Chandrasekharan, author.
ISBN
9783030855369 (electronic bk.)
3030855368 (electronic bk.)
9783030855352
303085535X
DOI
https://doi.org/10.1007/978-3-030-85536-9
Published
Cham : Springer, [2021]
Copyright
©2021
Language
English
Description
1 online resource : illustrations (chiefly color)
Item Number
10.1007/978-3-030-85536-9 doi
Call Number
QP114.C44 K37 2021
Dewey Decimal Classification
612.1/7
Summary
This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.
Bibliography, etc. Note
Includes bibliographical references and index.
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Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed September 29, 2021).
Available in Other Form
Cardiomyocytes in health and disease.
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Section I: Normal Cardiomyocyte and its Growth
1. Structure and Function of Cardiomyocyte
2. Development of Cardiomyocyte
3. Cell Cycle Regulation in Cardiomyocytes
4. Cardiac Fibroblast and Cardiomyocyte Growth
5. Role of Endocardium and Epicardium in Generation of Cardiomyocytes
Cardiomyocytes in the Mammalian Adult Heart
7. Energy Metabolism in Cardiomyocytes
Section II: Cardiomyocyte Responses 8. Response of Cardiomyocytes to Mechanical Stress
Cardiomyocyte Responses to Hormones 10. Sequelae of Genetic Defects in Cardiomyocytes
11. Response and Effects of Cardiomyocyte Progenitors in the Infarcted Heart
Section III: Cardiomyocyte Aging and Death
12. Cardiomyocyte Senescence
13. Mechanisms of Cardiomyocyte Death
14. Cardiomyocyte Response to Ischemic Injury
15. Cardiomyocytes in Heart Failure
Section IV: Cardiomyocyte Regeneration
16. Endogenous Mechanisms for Cardiomyocyte Regeneration
17. Mechanisms to Induce Cardiomyocyte Proliferation
18. Cell Sources of Cardiomyocytes for Heart Repair
19. Reprograming Fibroblasts for Cardiomyocytes and Progenitors
Section V: Translational Aspects of Cardiomyocyte Biology
20. Clinical Translation of Discoveries in Cardiomyocyte Biology.

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