001439704 000__ 04149cam\a2200601\i\4500 001439704 001__ 1439704 001439704 003__ OCoLC 001439704 005__ 20230309004516.0 001439704 006__ m\\\\\o\\d\\\\\\\\ 001439704 007__ cr\un\nnnunnun 001439704 008__ 210917s2021\\\\sz\a\\\\ob\\\\001\0\eng\d 001439704 019__ $$a1268574682$$a1284937670 001439704 020__ $$a9783030687083$$q(electronic bk.) 001439704 020__ $$a3030687082$$q(electronic bk.) 001439704 020__ $$z9783030687076 001439704 020__ $$z3030687074 001439704 0247_ $$a10.1007/978-3-030-68708-3$$2doi 001439704 035__ $$aSP(OCoLC)1268326500 001439704 040__ $$aYDX$$beng$$erda$$epn$$cYDX$$dGW5XE$$dDKU$$dOCLCO$$dEBLCP$$dOCLCF$$dUKAHL$$dOCLCQ$$dCOM$$dOCLCO$$dN$T$$dOCLCQ 001439704 049__ $$aISEA 001439704 050_4 $$aRC643$$b.N38 2021 001439704 08204 $$a616.99/419$$223 001439704 1001_ $$aNavakauskienė, Rūta,$$eauthor. 001439704 24510 $$aEpigenetics and proteomics of leukemia :$$ba synergy of experimental biology and computational informatics /$$cRūta Navakauskienė, Dalius Navakauskas, Veronika Borutinskaitė, Dalius Matuzevičius. 001439704 264_1 $$aCham :$$bSpringer,$$c[2021] 001439704 264_4 $$c©2021 001439704 300__ $$a1 online resource :$$billustrations (some color) 001439704 336__ $$atext$$btxt$$2rdacontent 001439704 337__ $$acomputer$$bc$$2rdamedia 001439704 338__ $$aonline resource$$bcr$$2rdacarrier 001439704 347__ $$atext file 001439704 347__ $$bPDF 001439704 504__ $$aIncludes bibliographical references and index. 001439704 5050_ $$aIntroduction -- Epigenetics in Leukemia -- Genetic and Epigenetic Alterations in Leukemia -- Epigenetic Modifiers and Their Inhibitors in Leukemia Treatment -- Chromatin Remodeling during Leukemia Cell Proliferation and Differentiation -- DNA Methylation and Epigenetic Regulation -- Chromatin Functional Regulation by Histone Modification -- Approaches to Epigenetic Treatment of Leukemia -- Proteomics in Leukemia -- Proteome in Leukemic vs. Differentiated Leukemia Cells -- Protein Phosphorylation in Leukemia -- Computational Methods for Proteome Analysis -- 2DE Fractionation and Visualization -- Proteomic Data Processing -- Proteomic Data Analysis -- Image Acquisition and Data Analysis -- Image Acquisition and Data Analysis -- Protein Localization in Leukemia -- Protein Translocation into the Nucleus during Leukemia Cell Differentiation -- Protein Visualization in Leukemic Cells -- Computational Methods for Protein Localization Estimation -- Fluorescent Image Processing -- Fluorescent Image Acquisition and Analysis -- Future Therapy in Leukemia -- Index. 001439704 506__ $$aAccess limited to authorized users. 001439704 520__ $$aThis book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy. Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers. 001439704 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed September 28, 2021). 001439704 650_0 $$aLeukemia$$xGenetic aspects. 001439704 650_0 $$aEpigenetics. 001439704 650_0 $$aProteomics. 001439704 650_6 $$aÉpigénétique. 001439704 650_6 $$aProtéomique. 001439704 655_0 $$aElectronic books. 001439704 7001_ $$aNavakauskas, Dalius,$$eauthor. 001439704 7001_ $$aBorutinskaitė, Veronika,$$eauthor. 001439704 7001_ $$aMatuzevičius, Dalius,$$eauthor. 001439704 77608 $$iPrint version:$$z3030687074$$z9783030687076$$w(OCoLC)1228880647 001439704 852__ $$bebk 001439704 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-68708-3$$zOnline Access$$91397441.1 001439704 909CO $$ooai:library.usi.edu:1439704$$pGLOBAL_SET 001439704 980__ $$aBIB 001439704 980__ $$aEBOOK 001439704 982__ $$aEbook 001439704 983__ $$aOnline 001439704 994__ $$a92$$bISE