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001439982 001__ 1439982
001439982 003__ OCoLC
001439982 005__ 20230309004534.0
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001439982 019__ $$a1269616427$$a1272992054$$a1284941493
001439982 020__ $$a9783030783976$$q(electronic bk.)
001439982 020__ $$a3030783979$$q(electronic bk.)
001439982 020__ $$z9783030783969
001439982 020__ $$z3030783960
001439982 0247_ $$a10.1007/978-3-030-78397-6$$2doi
001439982 035__ $$aSP(OCoLC)1269482277
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001439982 049__ $$aISEA
001439982 050_4 $$aQR201.M3$$bH43 2021
001439982 08204 $$a616.9/362$$223
001439982 24500 $$aHeat shock proteins of malaria /$$cAddmore Shonhai, Didier Picard, Gregory L. Blatch, editors.
001439982 250__ $$aSecond edition.
001439982 264_1 $$aCham :$$bSpringer,$$c[2021]
001439982 264_4 $$c©2021
001439982 300__ $$a1 online resource :$$bcolor illustrations
001439982 336__ $$atext$$btxt$$2rdacontent
001439982 337__ $$acomputer$$bc$$2rdamedia
001439982 338__ $$aonline resource$$bcr$$2rdacarrier
001439982 4901_ $$aAdvances in experimental medicine and biology,$$x2214-8019 ;$$vvolume 1340
001439982 500__ $$aIncludes index.
001439982 5050_ $$aChapter 1. Introductory Chapter: The Importance of Heat Shock Proteins in Survival and Pathogenesis of the Malaria Parasite Plasmodium falciparum -- Chapter 2. General Structural and Functional Features of Molecular Chaperones -- Chapter 3. The Role of Hsp70s in the Development and Pathogenicity of Plasmodium falciparum -- Chapter 4. Role of the J Domain Protein Family in the Survival and Pathogenesis of Plasmodium falciparum. Chapter 5. Role of Hsp90 in Plasmodium falciparum Malaria -- Chapter 6. The Role of Malaria Parasite Heat Shock Proteins in Protein Trafficking and Remodelling of Red Blood Cells -- Chapter 7. Role of Heat Shock Proteins in Immune Modulation in Malaria -- Chapter 8. Bioprospecting for Novel Heat Shock Protein Modulators: The New Frontier for Antimalarial Drug Discovery? -- Chapter 9. Heat Shock Proteins as Targets for Novel Antimalarial Drug Discovery -- Chapter 10 -- Heat Shock Proteins of Malaria: Highlights and Future Prospects.
001439982 506__ $$aAccess limited to authorized users.
001439982 520__ $$aThis new edition describes the role of heat shock proteins in the life cycle of malaria parasites, particularly in the context of intracellular parasite stages. Thoroughly revised, this work provides a general introduction to the structural and functional features of heat shock proteins with a special focus on their role as molecular chaperones in ensuring protein quality control. The emphasis is on the heat shock protein families from Plasmodium falciparum, and their role in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery either directly or in combination therapies. Readers will experience a functional analysis of the individual families of heat shock proteins and their cooperation in functional networks, including both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurer Clefts associated with Plasmodium species are discussed in detail. The book highlights the role of heat shock proteins in the development and function of these structures. Biochemical expertise and the inclusion of novel therapeutic solutions make this collection a unique reference for experts in heat shock protein research, parasitology and infectious diseases, cell stress, molecular biology and drug discovery. Not least, advances in malaria control will contribute to ending epidemics and ensuring healthy lives in line with the UN Sustainable Development Goals.
001439982 588__ $$aDescription based on print version record.
001439982 650_0 $$aMalaria$$xMolecular aspects.
001439982 650_0 $$aHeat shock proteins.
001439982 650_6 $$aPaludisme$$xAspect moléculaire.
001439982 650_6 $$aProtéines de choc thermique.
001439982 655_7 $$aConference papers and proceedings.$$2fast$$0(OCoLC)fst01423772
001439982 655_7 $$aConference papers and proceedings.$$2lcgft
001439982 655_7 $$aActes de congrès.$$2rvmgf
001439982 655_0 $$aElectronic books.
001439982 7001_ $$aShonhai, Addmore,$$eeditor.
001439982 7001_ $$aPicard, Didier,$$eeditor.
001439982 7001_ $$aBlatch, Gregory L.,$$eeditor.
001439982 77608 $$iPrint version:$$tHeat shock proteins of malaria.$$bSecond edition.$$dCham : Springer, [2021]$$z3030783960$$z9783030783969$$w(OCoLC)1251503126
001439982 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 1340.$$x2214-8019
001439982 852__ $$bebk
001439982 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-78397-6$$zOnline Access$$91397441.1
001439982 909CO $$ooai:library.usi.edu:1439982$$pGLOBAL_SET
001439982 980__ $$aBIB
001439982 980__ $$aEBOOK
001439982 982__ $$aEbook
001439982 983__ $$aOnline
001439982 994__ $$a92$$bISE