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SARS-CoV-2 spike protein convergent evolution : impact of virus variants on efficacy of COVID-19 therapeutics and vaccines / Daniele Focosi.

9783030873240 (electronic bk.)
3030873242 (electronic bk.)
9783030873233
3030873234

Cham : Springer, 2021.

English

1 online resource (140 pages)

10.1007/978-3-030-87324-0 doi

RA644.C67

614.5/92414

This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.

Includes bibliographical references.

Access limited to authorized users.

Online resource; title from PDF title page (Library Ideas, viewed October 22, 2021).

SpringerBriefs in microbiology.

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