@article{1440364,
      recid = {1440364},
      author = {Focosi, Daniele,},
      title = {SARS-CoV-2 spike protein convergent evolution : impact of  virus variants on efficacy of COVID-19 therapeutics and  vaccines /},
      publisher = {Springer,},
      address = {Cham :},
      pages = {1 online resource (140 pages)},
      year = {2021},
      abstract = {This book reviews the current knowledge of the globally  circulating SARS-CoV-2 variants, highlights their distinct  genetic characteristics and associated conformational  changes in the viral spike protein, and profoundly  discusses the mechanisms of convergent evolution that led  to the rise of these mutated strains at different  geographic regions during the Covid-19 pandemic.  Furthermore, the book explores how these variants do and  may impact the efficacy of established neutralizing  antibody-based (nAb) vaccines and therapeutics by analysing  latest in vivo and in vitro clinical data. Finally, the  author discusses ways on how nAb Covid-19 treatment derived  immune escape of SARS-CoV-2 could be minimized in the  future.},
      url = {http://library.usi.edu/record/1440364},
      doi = {https://doi.org/10.1007/978-3-030-87324-0},
}