001440364 000__ 02863cam\a2200541\a\4500
001440364 001__ 1440364
001440364 003__ OCoLC
001440364 005__ 20230309004558.0
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001440364 007__ cr\un\nnnunnun
001440364 008__ 211016s2021\\\\sz\\\\\\ob\\\\000\0\eng\d
001440364 019__ $$a1275426095$$a1276775249
001440364 020__ $$a9783030873240$$q(electronic bk.)
001440364 020__ $$a3030873242$$q(electronic bk.)
001440364 020__ $$z9783030873233
001440364 020__ $$z3030873234
001440364 0247_ $$a10.1007/978-3-030-87324-0$$2doi
001440364 035__ $$aSP(OCoLC)1276860028
001440364 040__ $$aEBLCP$$beng$$epn$$cEBLCP$$dGW5XE$$dYDX$$dEBLCP$$dOCLCF$$dN$T$$dOCLCO$$dOCLCQ$$dCOM$$dOCLCO$$dSFB$$dUKAHL$$dOCLCQ
001440364 049__ $$aISEA
001440364 050_4 $$aRA644.C67
001440364 08204 $$a614.5/92414$$223
001440364 1001_ $$aFocosi, Daniele,$$d1980-
001440364 24510 $$aSARS-CoV-2 spike protein convergent evolution :$$bimpact of virus variants on efficacy of COVID-19 therapeutics and vaccines /$$cDaniele Focosi.
001440364 260__ $$aCham :$$bSpringer,$$c2021.
001440364 300__ $$a1 online resource (140 pages)
001440364 336__ $$atext$$btxt$$2rdacontent
001440364 337__ $$acomputer$$bc$$2rdamedia
001440364 338__ $$aonline resource$$bcr$$2rdacarrier
001440364 4901_ $$aSpringerBriefs in microbiology
001440364 504__ $$aIncludes bibliographical references.
001440364 5050_ $$aChapter 1. Why the Spike protein is relevant for COVID19 therapeutics -- Chapter 2. SARS-CoV-2 variants -- Chapter 3. Conclusion.
001440364 506__ $$aAccess limited to authorized users.
001440364 520__ $$aThis book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.
001440364 588__ $$aOnline resource; title from PDF title page (Library Ideas, viewed October 22, 2021).
001440364 650_0 $$aCOVID-19 (Disease)
001440364 650_0 $$aMedical virology.
001440364 650_6 $$aCOVID-19.
001440364 650_6 $$aVirologie médicale.
001440364 655_0 $$aElectronic books.
001440364 77608 $$iPrint version:$$aFocosi, Daniele.$$tSARS-CoV-2 Spike Protein Convergent Evolution.$$dCham : Springer International Publishing AG, ©2021$$z9783030873233
001440364 830_0 $$aSpringerBriefs in microbiology.
001440364 852__ $$bebk
001440364 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-87324-0$$zOnline Access$$91397441.1
001440364 909CO $$ooai:library.usi.edu:1440364$$pGLOBAL_SET
001440364 980__ $$aBIB
001440364 980__ $$aEBOOK
001440364 982__ $$aEbook
001440364 983__ $$aOnline
001440364 994__ $$a92$$bISE