Behavioral clinical trials for chronic diseases : scientific foundations / Lynda H. Powell, Kenneth E. Freedland, Peter G. Kaufmann.
Powell, Lynda H., author.; Freedland, Kenneth E., author.; Kaufmann, Peter G., author.
2021
RC108
Available Online

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Title
Behavioral clinical trials for chronic diseases : scientific foundations / Lynda H. Powell, Kenneth E. Freedland, Peter G. Kaufmann.
Author
Powell, Lynda H., author.
ISBN
9783030393304 (electronic bk.)
3030393305 (electronic bk.)
9783030393281
3030393283
DOI
https://doi.org/10.1007/978-3-030-39330-4
Published
Cham : Springer, 2021.
Language
English
Description
1 online resource (1 volume) : illustrations (black and white, and color)
Item Number
10.1007/978-3-030-39330-4 doi
Call Number
RC108
Dewey Decimal Classification
616/.044
Summary
This is the first comprehensive guide to the design of behavioral randomized clinical trials (RCT) for chronic diseases. It includes the scientific foundations for behavioral trial methods, problems that have been encountered in past behavioral trials, advances in design that have evolved, and promising trends and opportunities for the future. The value of this book lies in its potential to foster an ability to speak the language of medicine through the conduct of high-quality behavioral clinical trials that match the rigor commonly seen in double-blind drug trials. It is relevant for testing any treatment aimed at improving a behavioral, social, psychosocial, environmental, or policy-level risk factor for a chronic disease including, for example, obesity, sedentary behavior, adherence to treatment, psychosocial stress, food deserts, and fragmented care. Outcomes of interest are those that are of clinical significance in the treatment of chronic diseases, including standard risk factors such as cholesterol, blood pressure, and glucose, and clinical outcomes such as hospitalizations, functional limitations, excess morbidity, quality of life, and mortality. This link between behavior and chronic disease requires innovative clinical trial methods not only from the behavioral sciences but also from medicine, epidemiology, and biostatistics. This integration does not exist in any current book, or in any training program, in either the behavioral sciences or medicine.
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Access limited to authorized users.
Source of Description
Description based on print version record.
Added Author
Freedland, Kenneth E., author.
Kaufmann, Peter G., author.
Available in Other Form
Behavioral clinical trials for chronic diseases.
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Introduction: the window of opportunity
A selected history of randomized behavioral clinical trials: what we learned
A clinically significant problem and a clincially significant benefit
The process of developing a behavioral treatment for chronic disease
The hypothesized pathway from behavioral treatment to chronic disease
Equipoise, blinding, and investigator discipline
Sensitivity to diversity
Protection of randomization
Choice of appropriate control group
Readiness to conduct a behavioral randomized clinical trial
Concluding remarks.

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