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001440540 001__ 1440540
001440540 003__ OCoLC
001440540 005__ 20230309004610.0
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001440540 019__ $$a1280598784$$a1281134267$$a1281980493$$a1287766292
001440540 020__ $$a9784431569190$$q(electronic bk.)
001440540 020__ $$a4431569197$$q(electronic bk.)
001440540 020__ $$z9784431569176
001440540 020__ $$z4431569170
001440540 0247_ $$a10.1007/978-4-431-56919-0$$2doi
001440540 035__ $$aSP(OCoLC)1280461060
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001440540 049__ $$aISEA
001440540 050_4 $$aQD431$$b.N35 2021
001440540 08204 $$a572/.6$$223
001440540 1001_ $$aNakasako, Masayoshi,$$eauthor.
001440540 24510 $$aHydration structures of proteins :$$batomic details /$$cMasayoshi Nakasako.
001440540 264_1 $$aTokyo :$$bSpringer,$$c[2021]
001440540 264_4 $$c©2021
001440540 300__ $$a1 online resource
001440540 336__ $$atext$$btxt$$2rdacontent
001440540 337__ $$acomputer$$bc$$2rdamedia
001440540 338__ $$aonline resource$$bcr$$2rdacarrier
001440540 347__ $$atext file
001440540 347__ $$bPDF
001440540 4901_ $$aSoft and biological matter,$$x2213-1744
001440540 504__ $$aIncludes bibliographical references and index.
001440540 5050_ $$aIntroduction -- Biophysical methods to visualize hydration structures of proteins -- Hydration structures inside proteins -- Hydration layer around proteins -- Structural characteristics in local hydration -- Prediction of hydration structures -- Network of hydrogen bonds around proteins -- Dipole-Dipole interactions in hydration layer -- Hydration structure changes of proteins at work -- Energy landscape and hydration of proteins.
001440540 506__ $$aAccess limited to authorized users.
001440540 520__ $$aThis book describes hydration structures of proteins by combining experimental results with theoretical considerations. It is designed to introduce graduate students and researchers to microscopic views of the interactions between water and biological macromolecules and to provide them with an overview of the field. Topics on protein hydration from the past 25 years are examined, most of which involve crystallography, fluorescence measurements, and molecular dynamics simulations. In X-ray crystallography and molecular dynamics simulations, recent advances have accelerated the study of hydration structures over the entire surface of proteins. Experimentally, crystal structure analysis at cryogenic temperatures is advantageous in terms of visualizing the positions of hydration water molecules on the surfaces of proteins in their frozen-hydrated crystals. A set of massive data regarding hydration sites on protein surfaces provides an appropriate basis, enabling us to identify statistically significant trends in geometrical characteristics. Trajectories obtained from molecular dynamics simulations illustrate the motion of water molecules in the vicinity of protein surfaces at sufficiently high spatial and temporal resolution to study the influences of hydration on protein motion. Together with the results and implications of these studies, the physical principles of the measurement and simulation of protein hydration are briefly summarized at an undergraduate level. Further, the author presents recent results from statistical approaches to characterizing hydrogen-bond geometry in local hydration structures of proteins. The book equips readers to better understand the structures and modes of interaction at the interface between water and proteins. Referred to as "hydration structures", they are the subject of much discussion, as they may help to answer the question of why water is indispensable for life at the molecular and atomic level
001440540 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed November 4, 2021).
001440540 650_0 $$aHydration.
001440540 650_0 $$aProteins.
001440540 650_6 $$aHydratation.
001440540 650_6 $$aProtéines.
001440540 655_0 $$aElectronic books.
001440540 77608 $$iPrint version:$$z4431569170$$z9784431569176$$w(OCoLC)1262966557
001440540 830_0 $$aSoft and biological matter.$$x2213-1744
001440540 852__ $$bebk
001440540 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-4-431-56919-0$$zOnline Access$$91397441.1
001440540 909CO $$ooai:library.usi.edu:1440540$$pGLOBAL_SET
001440540 980__ $$aBIB
001440540 980__ $$aEBOOK
001440540 982__ $$aEbook
001440540 983__ $$aOnline
001440540 994__ $$a92$$bISE