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001440572 001__ 1440572
001440572 003__ OCoLC
001440572 005__ 20230309004612.0
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001440572 019__ $$a1280460012$$a1280599802$$a1281136663$$a1287777784$$a1287868855$$a1292518075
001440572 020__ $$a9783030769123$$q(electronic bk.)
001440572 020__ $$a3030769127$$q(electronic bk.)
001440572 020__ $$z9783030769116$$q(print)
001440572 020__ $$z3030769119
001440572 0247_ $$a10.1007/978-3-030-76912-3$$2doi
001440572 035__ $$aSP(OCoLC)1280486199
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001440572 049__ $$aISEA
001440572 050_4 $$aQR186.8.G2
001440572 08204 $$a571.9/67$$223
001440572 24500 $$aAntibody glycosylation /$$cMarija Pezer, editor.
001440572 264_1 $$aCham, Switzerland :$$bSpringer,$$c2021.
001440572 300__ $$a1 online resource (xii, 587 pages) :$$billustrations (some color)
001440572 336__ $$atext$$btxt$$2rdacontent
001440572 337__ $$acomputer$$bc$$2rdamedia
001440572 338__ $$aonline resource$$bcr$$2rdacarrier
001440572 347__ $$atext file
001440572 347__ $$bPDF
001440572 4901_ $$aExperientia supplementum,$$x2504-3692 ;$$vvolume 112
001440572 5050_ $$aMicroheterogeneity of antibody molecules -- Part I: Analytical Methods -- Lectin and LC based methods for immunoglobulin (G) glycosylation analysis -- Mass spectrometry-based methods for immunoglobulin G N-glycosylation analysis -- CE based methods for Ig(G) glycosylation analysis -- Automation of Ig glycosylation analysis -- Bioinformatics in immunoglobulin glycosylation analysis -- Part II: Biosynthesis & Regulation -- N-glycan biosynthesis: Basic principles and factors affecting its outcome -- Genetic regulation of immunoglobulin G glycosylation -- Epigenetics of immunoglobulin G glycosylation -- IgG changes in aging and other inflammatory conditions -- Estrogen-driven changes in immunoglobulin G Fc glycosylation -- Part III: Effector Functions & Diseases -- Sweet rules -- linking glycosylation to antibody function -- Immunoglobulin G glycosylation in diseases -- Immunoglobulin A glycosylation and its role in diseases -- Part IV: Applications -- Importance and monitoring of therapeutic immunoglobulin G glycosylation -- Glycosylation of plant-produced immunoglobulins -- The rapidly expanding nexus of immunoglobulin G N-glycomics, suboptimal health status, and precision medicine -- Glycosylation of antigen-specific antibodies -- Perspectives on immunoglobulin G glycosylation in vaccination and immunotherapy.
001440572 506__ $$aAccess limited to authorized users.
001440572 520__ $$aThis book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
001440572 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed October 27, 2021).
001440572 650_0 $$aImmunoglobulin G.
001440572 650_0 $$aGlycosylation.
001440572 650_6 $$aImmunoglobuline G.
001440572 650_6 $$aGlycosylation.
001440572 655_0 $$aElectronic books.
001440572 7001_ $$aPezer, Marija,$$eeditor.
001440572 77608 $$iPrint version:$$tAntibody glycosylation.$$dCham, Switzerland : Springer, 2021$$z3030769119$$z9783030769116$$w(OCoLC)1247834166
001440572 830_0 $$aExperientia supplementum (2009) ;$$vv. 112.$$x2504-3692
001440572 852__ $$bebk
001440572 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-76912-3$$zOnline Access$$91397441.1
001440572 909CO $$ooai:library.usi.edu:1440572$$pGLOBAL_SET
001440572 980__ $$aBIB
001440572 980__ $$aEBOOK
001440572 982__ $$aEbook
001440572 983__ $$aOnline
001440572 994__ $$a92$$bISE